Differential effect of concurrent chemotherapy regimen on clinical outcomes of preoperative chemoradiotherapy for locally advanced rectal cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Oh, Do Hoon | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Jung, Seung-Yong | - |
dc.contributor.author | Park, Kyu Joo | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.date.accessioned | 2021-06-18T07:28:58Z | - |
dc.date.available | 2021-06-18T07:28:58Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1107-0625 | - |
dc.identifier.issn | 2241-6293 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44865 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the differential effect of chemotherapy regimen in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Methods: The medical records of 279 patients who underwent preoperative CRT followed by surgery for cT3/4 rectal cancer from 2003 to 2010 were retrospectively reviewed. Thirty-four patients were treated with one cycle of i.v. bolus 5-fluorouracil (5-FU) during 1st week (group A), 214 patients with two cycles of i.v. bolus 5-FU during 1st and 5th week (group B), and 31 patients with oral capecitabine on the days with radiotherapy (group C). Propensity score matching was performed between three groups. Results: Median follow-up was 60.1 months. Five-year locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) rates were 91.2, 83.3, 75.0, and 84.5%, respectively. Thirty-one patients per group were allocated to three groups via propensity score matching. On univariate analysis, concurrent chemotherapy regimen was not a significant prognostic factor for survival outcomes in the matched group analysis (OS, p=0.175; DFS, p=0.481; DMFS, p=0.515; LRFS, p=0.456). In addition, there was no significant difference in the sphincter preserving surgery rate, circumferential resection margin status, and pathologic response between three groups (p=0.441, 1.000, 0.818, respectively). As regards to treatment-related toxicity, 9 patients showed grade 3 neutropenia in group B, while there was no grade 3 or higher toxicity in groups A and C. Conclusion: The concurrent chemotherapy regimen (5-FU #1 vs 5-FU #2 vs capecitabine) did not have a significant effect on treatment outcomes in locally advanced rectal cancer patients receiving neoadjuvant CRT. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IMPRIMATUR PUBLICATIONS | - |
dc.title | Differential effect of concurrent chemotherapy regimen on clinical outcomes of preoperative chemoradiotherapy for locally advanced rectal cancer | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | JOURNAL OF BUON, v.24, no.2, pp 470 - 478 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000464461100009 | - |
dc.identifier.scopusid | 2-s2.0-85064943355 | - |
dc.citation.endPage | 478 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 470 | - |
dc.citation.title | JOURNAL OF BUON | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | chemoradiotherapy | - |
dc.subject.keywordAuthor | chemotherapy regimen | - |
dc.subject.keywordAuthor | neoadjuvant | - |
dc.subject.keywordAuthor | rectal cancer | - |
dc.subject.keywordPlus | PHASE-II | - |
dc.subject.keywordPlus | POSTOPERATIVE CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | ADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | OXALIPLATIN | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordPlus | IRINOTECAN | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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