Prognostic Value of Biochemical Response Models for Primary Biliary Cholangitis and the Additional Role of the Neutrophil-to-Lymphocyte Ratio
DC Field | Value | Language |
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dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Lee, Bora | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Lee, Yun Bin | - |
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.date.accessioned | 2021-06-18T07:32:21Z | - |
dc.date.available | 2021-06-18T07:32:21Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45091 | - |
dc.description.abstract | Background/Aims: Recently reported prognostic models for primary biliary cholangitis (PBC) have been shown to be effective in Western populations but have not been well-validated in Asian patients. This study aimed to compare the performance of prognostic models in Korean patents and to investigate whether inflammation-based scores can further help in prognosis prediction. Methods: This study included 271 consecutive patients diagnosed with PBC in Korea. The following prognostic models were evaluated: the Barcelona model, the Paris-I/II model, the Rotterdam criteria, the GLOBE score and the UK-PBC score. The neutrophil-to-lymphocyte ratio (NLR) was analyzed with reference to its association with prognosis. Results: For predicting liver transplant or death at the 5-year and 10-year follow-up examinations, the UK-PBC score (areas under the receiver operating characteristic curve [AUCs], 0.88 and 0.82) and GLOBE score (AUCs, 0.85 and 0.83) were sigpificantly more accurate in predicting prognosis than the other scoring systems (all p<0.05). There was no significant difference between the performance of the UK-PBC and GLOBE scores. In addition to the prognostic models, a high NLR (>2.46) at baseline was an independent predictor of reduced transplant-free survival in the multivariate analysis (adjusted hazard ratio, 3.74; p<0.01). When the NLR was applied to the prognostic models, it significantly differentiated the prognosis of patients. Conclusions: The UK-PBC and GLOBE scores showed good prognostic performance in Korean patients with PBC. In addition, a higt NLR was associated with a poorer prognosis. Including the NLR in prognostic models may further help to stratify patients with PBC. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.title | Prognostic Value of Biochemical Response Models for Primary Biliary Cholangitis and the Additional Role of the Neutrophil-to-Lymphocyte Ratio | - |
dc.type | Article | - |
dc.identifier.doi | 10.5009/gnl18271 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.12, no.6, pp 714 - + | - |
dc.identifier.kciid | ART002404143 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000450036100016 | - |
dc.identifier.scopusid | 2-s2.0-85057133146 | - |
dc.citation.endPage | + | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 714 | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | biliary | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Neutrophil-to-lymphocyte ratio | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | URSODEOXYCHOLIC ACID | - |
dc.subject.keywordPlus | SCORING SYSTEM | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COUNT | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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