Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji Seon | - |
dc.contributor.author | Kim, Ha Yeon | - |
dc.contributor.author | Shin, Byung Seop | - |
dc.contributor.author | Lee, Ae Ryoung | - |
dc.contributor.author | Yoon, Ji Hyun | - |
dc.contributor.author | Hahm, Tae Soo | - |
dc.contributor.author | Lee, Ja Eun | - |
dc.date.accessioned | 2021-06-18T07:42:05Z | - |
dc.date.available | 2021-06-18T07:42:05Z | - |
dc.date.issued | 2018-07-18 | - |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45226 | - |
dc.description.abstract | Background: Interleukin 2 (IL- 2) influences the development and severity of pain due to its antinociceptive and immunomodulatory effects. Its production is influenced by the increased expression of c- Cbl (Casitas B-lineage lymphoma proto-oncogene) and Cbl-b E3 ubiquitin ligases. We evaluated the effects on IL-2-mediated changes in c-Cbl and Cbl-b expression in a rat model of chronic neuropathic pain. Methods: Peripheral neuropathy was induced in adult male Sprague-Dawley rats weighing 250-300 g by chronic spinal nerve ligation. Half of the spinal cord ipsilateral to the nerve injury was harvested at 1, 3, and 6 weeks, and the expression levels of IL-, c-Cbl, Cbl-b, phospholipase C-gamma 1 (PLC-gamma 1), ZAP70, and protein kinase C theta (PKC theta), as well as ubiquitin conjugation, were evaluated. Results: Total IL-2 mRNA levels were significantly decreased at 3 and 6 weeks after nerve injury compared to those in sham-operated rats. The mRNA levels of c-Cbl and Cbl-b, as well as the level of ubiquitin conjugation, were significantly increased at 3 and 6 weeks. In contrast, the levels of phosphorylated ZAP70 and PLC-gamma 1 were decreased at 3 and 6 weeks after spinal nerve ligation. Ubiquitination of PLC-gamma 1 and PKC theta was increased at 3 and 6 weeks. Conclusions: Our results suggest that ubiquitin and the E3 ubiquitin ligases c-Cbl and Cbl-b function as neuroimmune modulators in the subacute phase of neuropathic pain after nerve injury. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12871-018-0555-z | - |
dc.identifier.bibliographicCitation | BMC ANESTHESIOLOGY, v.18, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000439247500005 | - |
dc.identifier.scopusid | 2-s2.0-85050315941 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC ANESTHESIOLOGY | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Cbl family | - |
dc.subject.keywordAuthor | Interleukin-2 | - |
dc.subject.keywordAuthor | Neuropathic pain | - |
dc.subject.keywordAuthor | Phospholipase C gamma 1 | - |
dc.subject.keywordAuthor | Ubiquitin | - |
dc.subject.keywordAuthor | ZAP70 | - |
dc.subject.keywordPlus | T-CELL INFILTRATION | - |
dc.subject.keywordPlus | NERVE INJURY | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | CHRONIC PAIN | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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