Management of benign papilloma without atypia diagnosed at ultrasound-guided core needle biopsy: Scoring system for predicting malignancy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Soo Kyung | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Moon, Hyeong-Gon | - |
dc.contributor.author | Kim, Min Kyoon | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Jung, Bong-wha | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Ko, Eunyoung | - |
dc.date.accessioned | 2021-06-18T07:43:52Z | - |
dc.date.available | 2021-06-18T07:43:52Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0748-7983 | - |
dc.identifier.issn | 1532-2157 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45362 | - |
dc.description.abstract | Background: The management of benign intraductal papilloma diagnosed on core needle biopsy (CNB) remains unclear. This study was designed to evaluate factors predicting malignancy in patients diagnosed with benign papilloma without atypia at ultrasound-guided CNB and to develop a scoring system predicting malignancy based on clinical, radiological and pathological factors on further excisional biopsy. Methods: The study enrolled patients diagnosed with benign papillomas (including benign and atypical papillary lesions) at CNB. Multivariate analysis was used to identify relevant clinical, radiological and pathological factors that may predict malignancy. Results: A total of 520 CNBs were diagnosed with benign or atypical papilloma. Of these, 452 were benign papilloma without atypia. Of the 250 lesions subsequently excised surgically from 234 women, 17 (6.8%) were diagnosed with malignancy. Multivariate analysis revealed that bloody nipple discharge, size on imaging >= 15 mm, BI-RADS >= 4b, peripheral location and palpability were independent predictors of malignancy. A scoring system was developed based on logistic regression models and beta coefficients for each variable. The area under the ROC curve was 0.947 (95% CI: 0.913-0.981, p < 0.001) and a negative predictive value was 100%. In a validation set of 62 patients, an area under the ROC curve was 0.926 (95% CI: 0.857-0.995, p < 0.001). Conclusions: A scoring system predicting malignancy in patients diagnosed by CNB with benign papilloma without atypia was developed. This system was able to identify a subset of patients with lesions likely to be benign, indicating that imaging follow-up rather than surgical excision may be appropriate. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Management of benign papilloma without atypia diagnosed at ultrasound-guided core needle biopsy: Scoring system for predicting malignancy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejso.2017.10.214 | - |
dc.identifier.bibliographicCitation | EJSO, v.44, no.1, pp 53 - 58 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000423247000008 | - |
dc.identifier.scopusid | 2-s2.0-85034979016 | - |
dc.citation.endPage | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 53 | - |
dc.citation.title | EJSO | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Benign papilloma | - |
dc.subject.keywordAuthor | Intraductal papilloma without atypia | - |
dc.subject.keywordAuthor | Scoring system | - |
dc.subject.keywordPlus | VACUUM-ASSISTED BIOPSY | - |
dc.subject.keywordPlus | BREAST-LESIONS | - |
dc.subject.keywordPlus | SURGICAL EXCISION | - |
dc.subject.keywordPlus | 11-GAUGE | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.