Diagnostic usefulness of the QuantiFERON-TB gold in-tube test (QFT-GIT) for tuberculous vertebral osteomyelitis
DC Field | Value | Language |
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dc.contributor.author | Choi, Sungim | - |
dc.contributor.author | Jung, Kyung Hwa | - |
dc.contributor.author | Son, Hyo-Ju | - |
dc.contributor.author | Lee, Seung Hyun | - |
dc.contributor.author | Hong, Jung Min | - |
dc.contributor.author | Kim, Min Chul | - |
dc.contributor.author | Kim, Min Jae | - |
dc.contributor.author | Chong, Yong Pil | - |
dc.contributor.author | Sung, Heungsup | - |
dc.contributor.author | Lee, Sang-Oh | - |
dc.contributor.author | Choi, Sang-Ho | - |
dc.contributor.author | Kim, Yang Soo | - |
dc.contributor.author | Woo, Jun Hee | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.date.accessioned | 2021-06-18T08:41:05Z | - |
dc.date.available | 2021-06-18T08:41:05Z | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 2374-4235 | - |
dc.identifier.issn | 2374-4243 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45439 | - |
dc.description.abstract | Background: Interferon (IFN)--releasing assay for diagnosing tuberculosis (TB) has shown promise; however, there are only a few reports on usefulness of the QuantiFERON-TB Gold In-Tube test (QFT-GIT) for diagnosing TB vertebral osteomyelitis. Methods: All patients presenting at a tertiary hospital between January 2010 and July 2016 with suspected TB vertebral osteomyelitis were retrospectively enrolled to evaluate the diagnostic performance of QFT-GIT. We used QFT-GIT to measure the IFN- response to ESAT-6, CFP-10 and TB7.7. Results: A total of 141 patients were enrolled; 32 (23%) were categorized as having confirmed TB, (1%) as probable TB, 14 (10%) as possible TB and 93 (66%) as not TB. Of these, 16 patients with probable and possible TB were excluded from the final analysis. Chronic granulomas with/without necrosis, acid-fast bacilli stain, M. tuberculosis polymerase chain reaction and cultures for M. tuberculosis were positive in 14 (44%), 12 (38%), 22 (69%) and 28 (88%) patients, respectively, among the 32 patients with confirmed TB. The overall sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio for a positive result, and likelihood ratio for a negative result of the QFT-GIT for TB vertebral osteomyelitis were 91% (95% confidence interval [CI], 75-98%), 65% (95% CI, 54-75%), 50% (95% CI, 42-58%), 95% (95% CI, 86-98%), 2.59 (95% CI, 1.89-3.55) and 0.14 (95% CI, 0.05-0.43), respectively. Conclusion: The QFT-GIT appears to be a useful adjunct test for diagnosing TB vertebral osteomyelitis because the negative test results may be useful for excluding a diagnosis of active TB vertebral osteomyelitis. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Diagnostic usefulness of the QuantiFERON-TB gold in-tube test (QFT-GIT) for tuberculous vertebral osteomyelitis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/23744235.2017.1410282 | - |
dc.identifier.bibliographicCitation | INFECTIOUS DISEASES, v.50, no.5, pp 346 - 351 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000428676300003 | - |
dc.identifier.scopusid | 2-s2.0-85035773830 | - |
dc.citation.endPage | 351 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 346 | - |
dc.citation.title | INFECTIOUS DISEASES | - |
dc.citation.volume | 50 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Tuberculosis | - |
dc.subject.keywordAuthor | Vertebral osteomyelitis | - |
dc.subject.keywordAuthor | Interferon-gamma releasing assay | - |
dc.subject.keywordPlus | CELL-BASED ASSAY | - |
dc.subject.keywordPlus | GAMMA RELEASE ASSAY | - |
dc.subject.keywordPlus | EXTRAPULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | OSTEOARTICULAR TUBERCULOSIS | - |
dc.subject.keywordPlus | MILIARY TUBERCULOSIS | - |
dc.subject.keywordPlus | PYOGENIC SPONDYLITIS | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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