Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-kappa B activation-mediated cell death
DC Field | Value | Language |
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dc.contributor.author | Kim, Arum | - |
dc.contributor.author | Nam, Yoon Jeong | - |
dc.contributor.author | Lee, Chung Soo | - |
dc.date.accessioned | 2021-06-18T08:42:14Z | - |
dc.date.available | 2021-06-18T08:42:14Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.issn | 1873-2747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45522 | - |
dc.description.abstract | The taxifolin effect on the cholesterol oxidation product-induced neuronal apoptosis was investigated using differentiated PC12 cells and human neuroblastoma SH-SY5Y cells. 7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-kappa B p65, cytosolic NF-kappa B p50 and cytosolic phosphorylated-I kappa B-alpha in PC12 cells. The cholesterol oxidation products also induced a decrease in the levels of Bid and Bcl-2, increase in the levels of p53 and Bax, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), production of reactive oxygen species, depletion of GSH and cell death in both cell lines. Taxifolin, N-acetylcysteine, trolox, Akt inhibitor and Bay11-7085 attenuated the cholesterol oxidation product-induced changes in the apoptosis-related protein levels, activation of the Akt and NF-kappa B, reactive oxygen species production, GSH depletion and cell death. These results show that taxifolin may reduce the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-kappa B activation-mediated cell death. The suppressive effect appears to be attributed to the inhibition of reactive oxygen species production and GSH depletion. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-kappa B activation-mediated cell death | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.brainresbull.017.07.008 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH BULLETIN, v.134, pp 63 - 71 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000411847400009 | - |
dc.identifier.scopusid | 2-s2.0-85023594399 | - |
dc.citation.endPage | 71 | - |
dc.citation.startPage | 63 | - |
dc.citation.title | BRAIN RESEARCH BULLETIN | - |
dc.citation.volume | 134 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Taxifolin | - |
dc.subject.keywordAuthor | Cholesterol oxidation products | - |
dc.subject.keywordAuthor | Akt and NF-kappa B | - |
dc.subject.keywordAuthor | Apoptosis-related proteins | - |
dc.subject.keywordAuthor | Cell protection | - |
dc.subject.keywordPlus | OXYSTEROLS | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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