Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, Jong Cheon | - |
dc.contributor.author | Hwang, Jung Hoo | - |
dc.contributor.author | Jo, Eunbi | - |
dc.contributor.author | Kim, Young-Rang | - |
dc.contributor.author | Kim, Dae Joon | - |
dc.contributor.author | Lee, Kyung-Bok | - |
dc.contributor.author | Park, Soo Jung | - |
dc.contributor.author | Jang, Ik-Soon | - |
dc.date.accessioned | 2021-06-18T08:43:08Z | - |
dc.date.available | 2021-06-18T08:43:08Z | - |
dc.date.issued | 2017-02-14 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45593 | - |
dc.description.abstract | Forkhead transcription factor (Foxo3a) is a downstream effector of JNK-induced tumor suppression. However, it is not clear whether the caveolin-1 (CAV1)-mediated JNK/ Foxo3a pathway is involved in cancer cell apoptosis. We found that cordycepin upregulates CAV1 expression, which was accompanied by JNK phosphorylation (p-JNK) and subsequent Foxo3a translocation into the nucleus, resulting in the upregulation of Bax protein expression. Furthermore, we found that CAV1 overexpression upregulated p-JNK, whereas CAV1 siRNA downregulated p-JNK. Additionally, SP600125, a specific JNK inhibitor, significantly increased Foxo3a phosphorylation, which downregulated Foxo3a translocation into the nucleus, indicating that CAV1 mediates JNK regulation of Foxo3a. Foxo3a siRNA downregulated Bax protein and attenuated A549 apoptosis, indicating that the CAV1-mediated JNK/ Foxo3a pathway induces the apoptosis of A549 lung cancer cells. Cordycepin significantly decreased tumor volume in nude mice. Taken together, these results indicate that cordycepin promotes CAV1 upregulation to enhance JNK/ Foxo3a signaling pathway activation, inducing apoptosis in lung cancer cells, and support its potential as a therapeutic agent for lung cancer. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.14661 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.7, pp 12211 - 12224 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000394187400127 | - |
dc.identifier.scopusid | 2-s2.0-85012889615 | - |
dc.citation.endPage | 12224 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 12211 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | CAV1 | - |
dc.subject.keywordAuthor | Cordycepin | - |
dc.subject.keywordAuthor | Foxo3a | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordPlus | HUMAN OSTEOSARCOMA CELLS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | AKT | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.