Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Chae-Seok | - |
dc.contributor.author | Kim, Hyopil | - |
dc.contributor.author | Yu, Nam-Kyung | - |
dc.contributor.author | Kang, Sukjae Joshua | - |
dc.contributor.author | Kim, TaeHyun | - |
dc.contributor.author | Ko, Hyoung-Gon | - |
dc.contributor.author | Lee, Jaehyun | - |
dc.contributor.author | Yang, Jung-eun | - |
dc.contributor.author | Ryu, Hyun-Hee | - |
dc.contributor.author | Park, Taesung | - |
dc.contributor.author | Gim, Jungsoo | - |
dc.contributor.author | Nam, Hye Jin | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.contributor.author | Wegener, Stephanie | - |
dc.contributor.author | Schmitz, Dietmar | - |
dc.contributor.author | Boeckers, Tobias M. | - |
dc.contributor.author | Lee, Min Goo | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.contributor.author | Lee, Jae-Hyung | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2021-06-18T08:43:30Z | - |
dc.date.available | 2021-06-18T08:43:30Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0028-3908 | - |
dc.identifier.issn | 1873-7064 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45621 | - |
dc.description.abstract | Autism spectrum disorders (ASDs) are a group of developmental disorders that cause variable and heterogeneous phenotypes across three behavioral domains such as atypical social behavior, disrupted communications, and highly restricted and repetitive behaviors. In addition to these core symptoms, other neurological abnormalities are associated with ASD, including intellectual disability (ID). However, the molecular etiology underlying these behavioral heterogeneities in ASD is unclear. Mutations in SHANK2 genes are associated with ASD and ID. Interestingly, two lines of Shank2 knockout mice (e6-7 KO and e7 KO) showed shared and distinct phenotypes. Here, we found that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 e6-7, but not in e7 KO mice compared with their own wild type littermates. Furthermore, treatment of Shank2 e6-7 KO mice with an allosteric modulator for the GABA(A) receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2 e6-7 KO mice. This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.neuropharm.2016.08.016 | - |
dc.identifier.bibliographicCitation | NEUROPHARMACOLOGY, v.112, pp 104 - 112 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000387626700013 | - |
dc.identifier.scopusid | 2-s2.0-84994187846 | - |
dc.citation.endPage | 112 | - |
dc.citation.startPage | 104 | - |
dc.citation.title | NEUROPHARMACOLOGY | - |
dc.citation.volume | 112 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Autism spectrum disorders | - |
dc.subject.keywordAuthor | Shank2 | - |
dc.subject.keywordAuthor | Gabra2 | - |
dc.subject.keywordAuthor | I/E ratio | - |
dc.subject.keywordAuthor | Spatial memory | - |
dc.subject.keywordPlus | AUTISM-SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | GABA(A) RECEPTOR | - |
dc.subject.keywordPlus | NEUROPSYCHIATRIC DISORDERS | - |
dc.subject.keywordPlus | RETT-SYNDROME | - |
dc.subject.keywordPlus | MOUSE MODELS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | NEUROTRANSMISSION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.