Doxorubicin and paclitaxel co-bound lactosylated albumin nanoparticles having targetability to hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Thao, Le Quang | - |
dc.contributor.author | Lee, Changkyu | - |
dc.contributor.author | Kim, Bomi | - |
dc.contributor.author | Lee, Sungin | - |
dc.contributor.author | Kim, Tae Hwan | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yoo, Sun Dong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.date.available | 2019-03-08T08:57:36Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4582 | - |
dc.description.abstract | Anticancer drug targeting to liver asialoglycoprotein receptors (ASGPR) is viewed as a good approach for hepatocellular carcinoma (HCC) treatment. Lactose residue is a promising ASGPR ligand due to its high receptor affinity. Herein, we introduce doxorubicin and paclitaxel co-bound lactosylated albumin (Lac-BSA) nanoparticles (Dox/Pac Lac-BSA NPs) with good liver targetability. Lac-BSA was synthesized by conjugating lactobionic acid to naive BSA then characterized by mass spectrometry. Dox/Pac Lac-BSA NPs were fabricated utilizing high-pressure homogenization and evaporation with Nab (R) (nanoparticle albumin bound) technology. Dox/Pac Lac-BSA NPs were spherical and well-dispersed, with a 148.7 +/- 13.8 nm particle size and -54.1 +/- 0.7 mV zeta potential at a 100% Lac-BSA feed ratio. Combined Dox and Pac synergistic cytotoxicity was confirmed in Hep G2 cells. Specifically, the inhibitory concentration (IC50; 0.21 +/- 0.02 mu g/ml) for Dox/Pac Lac-BSA NPs was 3.2 time lower than plain Dox/Pac BSA NPs (IC50; 0.68 +/- 0.04 mu g/ml). Also, Dox/Pac Lac-BSA NPs exhibited better internalizing in Hep G2 cells (61.8% vs. 14.4% for Dox) and spheroids compared to Dox/Pac BSA NPs. Finally, Dox/Pac Lac-BSA NPs displayed much greater localization into ICR mice livers compared to Dox/Pac BSA NPs. This was indicated by the presence of NP lactose residues revealed by a galactose inhibition study. Based on these results, we suggest that lactose-modified albumin-based nanoparticles fabricated with the Nab (R) technique can be a potential therapeutic vector for treating HCC via hepatocyte targeting. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Doxorubicin and paclitaxel co-bound lactosylated albumin nanoparticles having targetability to hepatocellular carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2017.01.017 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.152, pp 183 - 191 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000398014100022 | - |
dc.identifier.scopusid | 2-s2.0-85009865585 | - |
dc.citation.endPage | 191 | - |
dc.citation.startPage | 183 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 152 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Albumin nanoparticles | - |
dc.subject.keywordAuthor | Lactose | - |
dc.subject.keywordAuthor | Liver targetability | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Asialoglycoprotein receptor | - |
dc.subject.keywordAuthor | Nab (R) Technology | - |
dc.subject.keywordPlus | DRUG-DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | SERUM-ALBUMIN | - |
dc.subject.keywordPlus | ASIALOGLYCOPROTEIN RECEPTOR | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | TRAIL | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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