Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Nam-Hun | - |
dc.contributor.author | Seo, Chang-Seob | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.contributor.author | Jung, Da-Young | - |
dc.contributor.author | Lee, Jun-Kyung | - |
dc.contributor.author | Lee, Jin-Ah | - |
dc.contributor.author | Song, Kye Yong | - |
dc.contributor.author | Shin, Hyeun-Kyoo | - |
dc.contributor.author | Lee, Mee-Young | - |
dc.contributor.author | Seo, Young Bae | - |
dc.contributor.author | Kim, Hokyoung | - |
dc.contributor.author | Ha, Hyekyung | - |
dc.date.accessioned | 2021-06-18T10:43:27Z | - |
dc.date.available | 2021-06-18T10:43:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.issn | 1741-4288 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46234 | - |
dc.description.abstract | The fruit of Cornus officinalis Sieb. et Zucc. is commonly prescribed in Asian countries as a tonic formula. In this study, the hepatoprotective effect of ethanolic extracts of the fruit of C. officinalis (ECO) was investigated in a mouse model of acetaminophen- (APAP-) induced liver injury. Pretreatment of mice with ECO (100, 250, and 500 mg/kg for 7 days) significantly prevented the APAP (200 mg/kg) induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and LDH). Parallel to these changes, ECO treatment also prevented APAP-induced oxidative stress in the mice liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, and HO-1) and glutathione. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin staining. Our results indicate that ECO can prevent hepatic injuries associated with APAP-induced hepatotoxicity by preventing or alleviating oxidative stress. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.title | Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2012/804924 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2012 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000295647000001 | - |
dc.identifier.scopusid | 2-s2.0-80053515285 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2012 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HEPATIC-NECROSIS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | FRUCTUS | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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