삼백초 추출물의 3T3-L1 세포에 대한 지방축적 억제 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신옥수 | - |
dc.contributor.author | 신연호 | - |
dc.contributor.author | 이강혁 | - |
dc.contributor.author | 김건용 | - |
dc.contributor.author | 김기호 | - |
dc.contributor.author | 박정극 | - |
dc.contributor.author | 안재일 | - |
dc.contributor.author | 송계용 | - |
dc.date.accessioned | 2021-06-18T10:44:15Z | - |
dc.date.available | 2021-06-18T10:44:15Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1225-7117 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46305 | - |
dc.description.abstract | Obesity increases the risk of many adult diseases, such as atherosclerosis, diabetes, hypertension, ischemic heart disease and breast cancer. Inhibition of adipogenesis is an effective way in the anti-obesity management. Because of main components of Saururus chinensis is flavonoid, it has been showed some improvement by its antioxidant effects on the atherosclerosis, heart disease and diabetic hyperlipidemia. But mechanism of anti-obesity effect of S. chinensis is not clear. We investigated the effects of ethanol extracts of S. chinensis on adipogenesis in the 3T3-L1 pre-adipocyte. The 3T3-L1 cell line is commonly used to study adipogenesis in vitro. In this study, ethanol extracts of S. chinensis significantly decrease the lipid accumulation in the 3T3-L1 cells proved by measuring triglyceride contents and Oil red O staining. The proposed mechanism of inhibition of adipogenesis in the 3T3-L1 cells with ethanol extracts of S. chinensis is down-regulation of transcriptional factors and adipocytespecific genes such CCAAT/enhancer binding protein α (C/EBPα) and Peroxisome proliferator activated receptor γ (PPARγ) in concentration dependent pattern. These results suggest that ethanol extracts of S. chinensis inhibits adipognesis in the 3T3-L1 cells and can be used as a safe and efficient natural substance to manage anti-obesity. | - |
dc.format.extent | 6 | - |
dc.publisher | 한국생물공학회 | - |
dc.title | 삼백초 추출물의 3T3-L1 세포에 대한 지방축적 억제 효과 | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | KSBB Journal, v.27, no.6, pp 381 - 386 | - |
dc.identifier.kciid | ART001742124 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 386 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 381 | - |
dc.citation.title | KSBB Journal | - |
dc.citation.volume | 27 | - |
dc.publisher.location | 대한민국 | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.