Identification of Novel A2/C2 Inter-Genotype Recombinants of Hepatitis B Virus from a Korean Chronic Patient Co-Infected with Both Genotype A2 and C2
DC Field | Value | Language |
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dc.contributor.author | Lee, So-Young | - |
dc.contributor.author | Lee, Seung-Hee | - |
dc.contributor.author | Kim, Ji-Eun | - |
dc.contributor.author | Kim, Hong | - |
dc.contributor.author | Kim, Kijeong | - |
dc.contributor.author | Kook, Yoon-Hoh | - |
dc.contributor.author | Kim, Bum-Joon | - |
dc.date.available | 2019-03-08T08:58:22Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4654 | - |
dc.description.abstract | Nearly all cases of Hepatitis B virus (HBV) infections in South Korea have the C2 genotype. Here, we have identified a chronically infected patient who was co-infected with HBV of both the A2 and C2 genotypes by screening 135 Korean chronically infected patients using direct sequencing protocols targeting the 1032-bp polymerase reverse transcriptase (RT) region. Further polymerase chain reaction (PCR)-cloning analysis (22 clones) of the RT showed that this patient had genotype C2 (12 clones), genotype A2 (six clones) and A2/C2 inter-genotype HBV recombinants (four clones). BootScan analysis showed that three of the four recombinants have different types of recombination breakpoints in both the RT and overlapping hepatitis B surface antigen (HBsAg) region. Given the significance of HBsAg as a diagnostic or vaccination target against HBV infection, clinical implications of these identified recombinants should be studied in the future. To our knowledge, this is the first report on A2/C2 inter-genotype HBV recombinants. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Identification of Novel A2/C2 Inter-Genotype Recombinants of Hepatitis B Virus from a Korean Chronic Patient Co-Infected with Both Genotype A2 and C2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms18040737 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.18, no.4 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000402639400062 | - |
dc.identifier.scopusid | 2-s2.0-85017018466 | - |
dc.citation.number | 4 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Hepatitis B virus | - |
dc.subject.keywordAuthor | polymerase RT region | - |
dc.subject.keywordAuthor | small surface protein | - |
dc.subject.keywordAuthor | subgenotype A2 | - |
dc.subject.keywordAuthor | subgenotype C2 | - |
dc.subject.keywordAuthor | inter-genotypical recombination | - |
dc.subject.keywordPlus | CHRONIC HBV INFECTION | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA PATIENT | - |
dc.subject.keywordPlus | FULL GENOME SEQUENCES | - |
dc.subject.keywordPlus | SURFACE-ANTIGEN | - |
dc.subject.keywordPlus | CLINICAL SEVERITY | - |
dc.subject.keywordPlus | DISEASE PROGRESSION | - |
dc.subject.keywordPlus | REGION MUTATIONS | - |
dc.subject.keywordPlus | GENDER DISPARITY | - |
dc.subject.keywordPlus | LIVER-DISEASES | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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