The effect of genistein on melanin synthesis and in vivo whitening
DC Field | Value | Language |
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dc.contributor.author | Yang, E.-S. | - |
dc.contributor.author | Hwang, J.-S. | - |
dc.contributor.author | Choi, H.-C. | - |
dc.contributor.author | Hong, R.-H. | - |
dc.contributor.author | Kang, S.-M. | - |
dc.date.accessioned | 2021-06-18T13:41:33Z | - |
dc.date.available | 2021-06-18T13:41:33Z | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 1598-642X | - |
dc.identifier.issn | 2234-1305 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46965 | - |
dc.description.abstract | The effect of genistein on melanin synthesis was studied using in vitro and in vivo model. Genistein inhibited melanin synthesis in cultured melan-a cells dose dependently. Tyrosinase activity was decreased by genistein treatment in melan-a cells, but genistein did not inhibit tyrosinase directly. Genistein did not affect the expression of tyrosinase in melan-a cells. Genistein inhibited the activity of α-glucosidase in vitro and the glycosylation of tyrosinase in melan-a cells. The resulting unsaturated glycosylation of tyrosinase makes it unstable and disturb correct transportation. To further clarify the effect of genistein on the melanogenesis, we established UVB-induced hyperpigmentation on the shaved backs of brown guinea pigs. The animals were exposed to UVB radiation once a week for three consecutive weeks. Genistein (1 and 2%) or vehicle alone as a control were then topically applied to the hyperpigmented areas daily. Genistein showed significant lightening effect on the UVB-induced hyperpigmentation in five weeks. Depigmenting effect was prominent in 2% genistein treatment with Fontana-Masson staining. In conclusion, genistein may be a useful agent for skin whitening. | - |
dc.format.extent | 10 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | The effect of genistein on melanin synthesis and in vivo whitening | - |
dc.title.alternative | The Effect of Genistein on Melanin Synthesis and In vivo Whitening. | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Korean Journal of Microbiology and Biotechnology, v.36, no.1, pp 72 - 81 | - |
dc.identifier.kciid | ART001236451 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-74049083228 | - |
dc.citation.endPage | 81 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.title | Korean Journal of Microbiology and Biotechnology | - |
dc.citation.volume | 36 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | α-glucosidase | - |
dc.subject.keywordAuthor | Genistein | - |
dc.subject.keywordAuthor | Melanin | - |
dc.subject.keywordAuthor | Tyrosinase | - |
dc.subject.keywordAuthor | Whitening | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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