인슐린 저항성과 발기부전
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, S.-C. | - |
dc.date.accessioned | 2021-06-18T13:42:13Z | - |
dc.date.available | 2021-06-18T13:42:13Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.issn | 2466-054X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47021 | - |
dc.description.abstract | Insulin resistance is a hallmark of metabolic syndrome, including type 2 diabetes mellitus and obesity which are characterized by endothelial dysfunction. The endothelial dysfunction leads to erectile dysfunction (ED). Thus, understanding of insulin resistance is mandatory for urologists to understand a pathophysiology of ED. There are two distinct features of insulin signal transduction pathway. One is phosphatidylinositol 3-kinase-dependent pathway which regulates glucose uptake in skeletal muscle and nitric oxide (NO) production and vasodilation in vascular endothelium. In cavernous smooth muscles, insulin also induces the endothelium-dependent relaxation, however it may emanate from the direct inhibition of L-type Ca2+ channels by prostacyclin in addition to NO production. The other one is mitogen-activated protein (MAP)-kinase pathway which regulates growth and mitogenesis and controls secretion of endothelin-1 in vascular endothelium. Stimulation of sympathetic activity by insulin may also contribute to hemodynamic regulation. A shift in balance between vasoconstrictor and vasodilator actions of insulin may be an important factor in the vascular pathophysology of insulin resistance, leading to ED. Hyperglycemia, elevated free fatty acid levels, and proinflammatory states share mechanisms between insulin resistance and endothelial dysfunction. There is evidence to suggest that testosterone is an important regulator of insulin sensitivity in men and hypotestosteronemia may have a role in the pathogenesis of insulin-resistant states. | - |
dc.format.extent | 11 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | Korean Urological Association | - |
dc.title | 인슐린 저항성과 발기부전 | - |
dc.title.alternative | Insulin Resistance and Erectile Dysfunction | - |
dc.type | Article | - |
dc.identifier.doi | 10.4111/kju.2006.47.9.917 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urology, v.47, no.9, pp 917 - 927 | - |
dc.identifier.kciid | ART001024757 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-33751330672 | - |
dc.citation.endPage | 927 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 917 | - |
dc.citation.title | Korean Journal of Urology | - |
dc.citation.volume | 47 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Calcium | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Uric acid | - |
dc.subject.keywordAuthor | Urinary calculi | - |
dc.subject.keywordPlus | calcium channel L type | - |
dc.subject.keywordPlus | fatty acid | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | insulin | - |
dc.subject.keywordPlus | mitogen activated protein kinase | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | phosphatidylinositol 3 kinase | - |
dc.subject.keywordPlus | prostacyclin | - |
dc.subject.keywordPlus | testosterone | - |
dc.subject.keywordPlus | adrenergic stimulation | - |
dc.subject.keywordPlus | corpus cavernosum | - |
dc.subject.keywordPlus | endothelial dysfunction | - |
dc.subject.keywordPlus | erectile dysfunction | - |
dc.subject.keywordPlus | fatty acid blood level | - |
dc.subject.keywordPlus | glucose transport | - |
dc.subject.keywordPlus | growth regulation | - |
dc.subject.keywordPlus | hemodynamics | - |
dc.subject.keywordPlus | hormone action | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hyperglycemia | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | insulin sensitivity | - |
dc.subject.keywordPlus | metabolic regulation | - |
dc.subject.keywordPlus | metabolic syndrome X | - |
dc.subject.keywordPlus | mitogenesis | - |
dc.subject.keywordPlus | muscle metabolism | - |
dc.subject.keywordPlus | non insulin dependent diabetes mellitus | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | pathogenesis | - |
dc.subject.keywordPlus | pathophysiology | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | review | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | skeletal muscle | - |
dc.subject.keywordPlus | smooth muscle | - |
dc.subject.keywordPlus | smooth muscle relaxation | - |
dc.subject.keywordPlus | testosterone blood level | - |
dc.subject.keywordPlus | urology | - |
dc.subject.keywordPlus | vascular endothelium | - |
dc.subject.keywordPlus | vasoconstriction | - |
dc.subject.keywordPlus | vasodilatation | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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