Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems
- Authors
- Jeong, Won Je; Kim, Jeong Yun; Choo, Jaebum; Lee, Eun Kyu; Han, Chang Soo; Beebe, David J; Seong, Gi Hun; Lee, Sang Hoon
- Issue Date
- Apr-2005
- Publisher
- AMER CHEMICAL SOC
- Citation
- LANGMUIR, v.21, no.9, pp 3738 - 3741
- Pages
- 4
- Journal Title
- LANGMUIR
- Volume
- 21
- Number
- 9
- Start Page
- 3738
- End Page
- 3741
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47072
- DOI
- 10.1021/la050105l
- ISSN
- 0743-7463
1520-5827
- Abstract
- We report a novel technique for manufacturing polymeric microparticles containing biocatalysts by the behavior of immiscible liquids in microfluidic systems and in situ photopolymerization. The approach utilizes a UV-polymerizable hydrogel/enzyme solution and an immiscible oil solution. The oil and hydrogel solutions form emulsions in pressure-driven flow in microchannels at high values of the dimensionless capillary number (Ca). The resultant hydrogel droplets are then polymerized in situ via exposure to 365 nm UV light. This technique allows for the generation of monodisperse particles whose size can be controlled by the regulation of flow rates. In addition, both manufacturing microparticles and immobilizing biocatalysts can be performed simultaneously and continuously.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47072)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.