Polyacetylenes from a marine sponge Petrosia sp inhibit DNA replication at the level of initiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, DK | - |
dc.contributor.author | Lee, MY | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Lee, DS | - |
dc.contributor.author | Lee, JR | - |
dc.contributor.author | Lee, BJ | - |
dc.contributor.author | Jung, JH | - |
dc.date.accessioned | 2021-06-18T13:44:27Z | - |
dc.date.available | 2021-06-18T13:44:27Z | - |
dc.date.issued | 2002-11 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.issn | 1872-7980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47192 | - |
dc.description.abstract | In the course of our search for bioactive metabolites from the marine sponges collected from Korean water, we found that the polyacetylenes of marine sponge, genus Petrosia, deliver significant selective cytotoxicity against several human tumor cell lines. The effects of polyacetylene on DNA replication were examined using simian virus 40 DNA replication system in vitro. We found that polyacetylenes inhibited DNA replication, and predominantly inhibited the initiation stage of DNA replication. Polyacetylenes inhibited the DNA cleavage by topoisomerase 1, and also significantly reduced polymerase a-primase activity. The ssDNA binding activity of replication protein A was little affected by polyacetylenes. We suggest that polyacetylenes might inhibit proteins required to establish replication forks during the initiation reaction, and their cytotoxicities might be related to the inhibitory effect they have on this fundamental cellular process. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI IRELAND LTD | - |
dc.title | Polyacetylenes from a marine sponge Petrosia sp inhibit DNA replication at the level of initiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0304-3835(02)00233-1 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.185, no.1, pp 95 - 101 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000178326800012 | - |
dc.identifier.scopusid | 2-s2.0-0037044571 | - |
dc.citation.endPage | 101 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 185 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | polyacetylenes | - |
dc.subject.keywordAuthor | DNA replication | - |
dc.subject.keywordAuthor | antitumor agent | - |
dc.subject.keywordAuthor | marine sponge | - |
dc.subject.keywordPlus | SIMIAN VIRUS-40 DNA | - |
dc.subject.keywordPlus | POLYMERASE-ALPHA-PRIMASE | - |
dc.subject.keywordPlus | PROTEIN-A | - |
dc.subject.keywordPlus | T-ANTIGEN | - |
dc.subject.keywordPlus | SV40 ORIGIN | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DELTA | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.