Degradation of immunoglobulins, protease inhibitors and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii.
DC Field | Value | Language |
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dc.contributor.author | Na, B.K. | - |
dc.contributor.author | Cho, J.H. | - |
dc.contributor.author | Song, C.Y. | - |
dc.contributor.author | Kim, T.S. | - |
dc.date.accessioned | 2021-06-18T14:41:06Z | - |
dc.date.available | 2021-06-18T14:41:06Z | - |
dc.date.issued | 2002-06 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.issn | 1738-0006 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47212 | - |
dc.description.abstract | The effect of a secretory proteinase from the pathogenic amoebae Acanthamoeba castellanii on host's defense-oriented or regulatory proteins such as immunoglobulins, interleukin-1, and protease inhibitors was investigated. The enzyme was found to degrade secretory immunoglobulin A (sIgA), IgG, and IgM. It also degraded interleukin-1 alpha (IL-1 alpha) and IL-1 beta. Its activity was not inhibited by endogenous protease inhibitors, such as alpha 2-macroglobulin, alpha 1-trypsin inhibitor, and alpha 2-antiplasmin. Furthermore, the enzyme rapidly degraded those endogenous protease inhibitors as well. The degradation of host's defense-oriented or regulatory proteins by the Acanthamoeba proteinase suggested that the enzyme might be an important virulence factor in the pathogenesis of Acanthamoeba infection. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한기생충학ㆍ열대의학회 | - |
dc.title | Degradation of immunoglobulins, protease inhibitors and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii. | - |
dc.title.alternative | Degradation of immunoglobulins, protease inhibitors and interleukin-l by a secretory proteinase of Acanthamoeba castellanii | - |
dc.type | Article | - |
dc.identifier.doi | 10.3347/kjp.2002.40.2.93 | - |
dc.identifier.bibliographicCitation | The Korean journal of parasitology, v.40, no.2, pp 93 - 99 | - |
dc.identifier.kciid | ART000917619 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-0036597993 | - |
dc.citation.endPage | 99 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 93 | - |
dc.citation.title | The Korean journal of parasitology | - |
dc.citation.volume | 40 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordPlus | immunoglobulin | - |
dc.subject.keywordPlus | interleukin 1 | - |
dc.subject.keywordPlus | proteinase | - |
dc.subject.keywordPlus | proteinase inhibitor | - |
dc.subject.keywordPlus | Acanthamoeba | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | enzymology | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | pathogenicity | - |
dc.subject.keywordPlus | physiology | - |
dc.subject.keywordPlus | virulence | - |
dc.subject.keywordPlus | Acanthamoeba | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Endopeptidases | - |
dc.subject.keywordPlus | Immunoglobulins | - |
dc.subject.keywordPlus | Interleukin-1 | - |
dc.subject.keywordPlus | Protease Inhibitors | - |
dc.subject.keywordPlus | Virulence | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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