Erythropoietin response is inadequate in cancer patients receiving chemotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Kwon, JH | - |
dc.contributor.author | Jung, CW | - |
dc.date.accessioned | 2021-06-18T14:41:13Z | - |
dc.date.available | 2021-06-18T14:41:13Z | - |
dc.date.issued | 2001-12 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.issn | 1865-3774 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47220 | - |
dc.description.abstract | The level of serum erythropoietin (EPO) is inappropriately decreased in cancer patient,, and has been advocated as the main cause of their anemia. In cancer patients, chemotherapy results in a cumulative anemia severe enough to require transfusion. We investigated the changes in serum EPO, hemoglobin, ceruloplasmin, and copper levels in cancer patients receiving chemotherapy. There was a weak but significant inverse relationship between hemoglobin and log[EPO] (r = -0.41 P <.001). Observed/expected serum EPO ratios decline with repeated chemotherapy indicating inadequate EPO response for the degree of anemia. There was no difference in the severity of anemia and in the degree of EPO response between platinum- and non-platinum-treated patients. Ceruloplasmin copper. and ferritin levels did not change during chemotherapy. Our results suggest that the EPO response is inadequate for the degree of anemia and justifies the use of recombinant human EPO in cancer patients receiving chemotherapy. Int J Hematol. 200174:416-420. (C) 2001 The Japanese Society of Hematology. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CARDEN JENNINGS PUBL CO LTD | - |
dc.title | Erythropoietin response is inadequate in cancer patients receiving chemotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/BF02982085 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HEMATOLOGY, v.74, no.4, pp 416 - 420 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000173069600008 | - |
dc.identifier.scopusid | 2-s2.0-0035747793 | - |
dc.citation.endPage | 420 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 416 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.citation.volume | 74 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | erythropoietin | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | ceruloplasmin | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordPlus | SERUM ERYTHROPOIETIN | - |
dc.subject.keywordPlus | INDUCED ANEMIA | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | IRON | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.