Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model
DC Field | Value | Language |
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dc.contributor.author | Kwak, CS | - |
dc.contributor.author | Kang, CM | - |
dc.contributor.author | Kang, HS | - |
dc.contributor.author | Song, KY | - |
dc.contributor.author | Lee, MS | - |
dc.contributor.author | Seong, SC | - |
dc.contributor.author | Park, SC | - |
dc.date.accessioned | 2021-06-18T14:43:19Z | - |
dc.date.available | 2021-06-18T14:43:19Z | - |
dc.date.issued | 2000-10 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47345 | - |
dc.description.abstract | The purpose of this study was to determine whether esterification of dehydroepiandrosterone with aspartate (DHEA-aspartate) could reduce peroxisomal proliferation induced by DHEA itself, without loss of antiosteoporotic activity. Female Sprague-Dawley rats were ovariectomized, then DHEA or DHEA-aspartate was administered intraperitoneally at 0.34 mmol/kg BW 3 times a week for 8 weeks. DHEA-aspartate treatment in ovariectomized rats significantly increased trabeculae area in tibia as much as DHEA treatment. Urinary Ca excretion was not significantly increased by DHEA or DHEA-aspartate treatment in ovariectomized rats, while it was significantly increased by ovariectomy. Osteocalcin concentration and alkaline phosphatase activity in serum and cross linked N-telopeptide type 1 collagen level in urine were not significantly different between DHEA-aspartate and DHEA treated groups. DHEA-aspartate treatment significantly reduced liver weight and hepatic palmitoyl-coa oxidase activity compared to DHEA treatment. DHEA-aspartate treatment maintained a nearly normal morphology of peroxisomes, while DHEA treatment increased the number and size of peroxisomes in the liver. According to these results, it is concluded that DHEA-aspartate ester has an inhibitory effect on bone loss in ovariectomized rats with a marked reduction of hepatomegaly and peroxisomal proliferation compared to DHEA. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2000.15.5.533 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.15, no.5, pp 533 - 541 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000090086500009 | - |
dc.identifier.scopusid | 2-s2.0-0034304081 | - |
dc.citation.endPage | 541 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 533 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | dehydroepiandrosterone | - |
dc.subject.keywordAuthor | aspartic acid | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | peroxisomal proliferation | - |
dc.subject.keywordAuthor | ovariectomy | - |
dc.subject.keywordPlus | ACYL-COA OXIDASE | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | REPLACEMENT THERAPY | - |
dc.subject.keywordPlus | TRABECULAR BONE | - |
dc.subject.keywordPlus | GLA-PROTEIN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | TURNOVER | - |
dc.subject.keywordPlus | HISTOMORPHOMETRY | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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