Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CS | - |
dc.contributor.author | Han, ES | - |
dc.contributor.author | Jang, YY | - |
dc.contributor.author | Han, JH | - |
dc.contributor.author | Ha, HW | - |
dc.contributor.author | Kim, DE | - |
dc.date.accessioned | 2021-06-18T14:43:26Z | - |
dc.date.available | 2021-06-18T14:43:26Z | - |
dc.date.issued | 2000-08 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.issn | 1471-4159 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47352 | - |
dc.description.abstract | The present study elucidated the protective effect of beta-carbolines (harmaline, harmalol, and harmine) on oxidative neuronal damage. MPTP treatment increased activities of total superoxide dismutase, catalase, and glutathione peroxidase and levels of malondialdehyde and carbonyls in the basal ganglia, diencephalon plus midbrain of brain compared with control mouse brain. Coadministration of harmalol (48 mg/kg) attenuated the MPTP effect on the enzyme activities and formation of tissue peroxidation products. Harmaline, harmalol, and harmine attenuated both the 500 mu M MPP+- induced inhibition of electron flow and membrane potential formation and the 100 mu M dopamine-induced thiol oxidation and carbonyl formation in mitochondria. The scavenging action of beta-carbolines on hydroxyl radicals was represented by inhibition of 2-deoxy-o-ribose degradation. Harmaline and harmalol (100 mu M) attenuated 200 mu M dopamine-induced viability loss in PC12 cells. The beta-carbolines (50 mu M) attenuated 50 mu M dopamine-induced apoptosis in PC12 cells. The compounds alone did not exhibit significant cytotoxic effects. The results indicate that beta-carbolines attenuate brain damage in mice treated with MPTP and MPP+-induced mitochondrial damage, The compounds may prevent dopamine-induced mitochondrial damage and PC12 cell death through a scavenging action on reactive oxygen species and inhibition of monoamine oxidase and thiol oxidation. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1046/j.1471-4159.2000.0750521.x | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.75, no.2, pp 521 - 531 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000088231600010 | - |
dc.identifier.scopusid | 2-s2.0-0343081001 | - |
dc.citation.endPage | 531 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 521 | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 75 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | beta-carbolines | - |
dc.subject.keywordAuthor | MPTP | - |
dc.subject.keywordAuthor | dopamine | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordPlus | MEMBRANE-PERMEABILITY TRANSITION | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | HYDROXYL RADICALS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GLUTATHIONE-PEROXIDASE | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.