A recombinant 10-kDa protein of Taenia solium metacestodes specific to active neurocysticercosis
DC Field | Value | Language |
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dc.contributor.author | Chung, JY | - |
dc.contributor.author | Bahk, YY | - |
dc.contributor.author | Huh, S | - |
dc.contributor.author | Kang, SY | - |
dc.contributor.author | Kong, Y | - |
dc.contributor.author | Cho, SY | - |
dc.date.accessioned | 2021-06-18T14:44:30Z | - |
dc.date.available | 2021-06-18T14:44:30Z | - |
dc.date.issued | 1999-10 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47420 | - |
dc.description.abstract | Neurocysticercosis (NCC) is an important cause of neurological disease worldwide. A 10-kDa antigen of Taenia solium metacestodes (TsMs) has been shown to be specific for immunodiagnosis of NCC, Screening of a TsM complementary DNA (cDNA) library isolated a cDNA encoding this protein. The cloned cDNA contained a 258-bp complete open-reading frame that encodes an 86-amino acid polypeptide with a calculated molecular weight of 9582 Da. It showed 73% homology with a 10-kDa antigen of T. crassiceps. The recombinant protein was expressed bacterially as a fusion protein at a high level. In immunoblot with recombinant protein, 97% (184/190) of sera from patients with active NCC showed strong reactivity, whereas 14% (4/29) of those from patients with chronic calcified NCC reacted weakly. In 180 sera from other patients with parasitic infections and from normal controls, it showed 98% specificity A single recombinant TsM antigen has a high potential for serological differentiation of active NCC. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | UNIV CHICAGO PRESS | - |
dc.title | A recombinant 10-kDa protein of Taenia solium metacestodes specific to active neurocysticercosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1086/315020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, v.180, no.4, pp 1307 - 1315 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000083019500048 | - |
dc.identifier.scopusid | 2-s2.0-0033399692 | - |
dc.citation.endPage | 1315 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1307 | - |
dc.citation.title | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 180 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | LINKED IMMUNOELECTROTRANSFER BLOT | - |
dc.subject.keywordPlus | BOVINE CYSTICERCOSIS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | MAJOR CAUSE | - |
dc.subject.keywordPlus | CYST FLUID | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | CRASSICEPS | - |
dc.subject.keywordPlus | COMMUNITY | - |
dc.subject.keywordPlus | MEXICO | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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