Determination of urazamide in pharmaceutical preparation with room temperature ionic liquid
- Authors
- Seo, Narae; Lee, Yoo Rim; Park, Hyun Sun; Quoc-Ky Truong; Lee, Jae-Yong; Chung, Hyun Kyu; Choi, Yusung; Kim, Byeonghee; Han, Sang Beom; Kim, Kyeong Ho
- Issue Date
- Mar-2017
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Very polar compound; Urazamide; Room temperature ionic liquids (RTILs); Reverse phase high performance liquid chromatography (RP-HPLC)
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.40, no.3, pp 364 - 372
- Pages
- 9
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 40
- Number
- 3
- Start Page
- 364
- End Page
- 372
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4744
- DOI
- 10.1007/s12272-017-0895-0
- ISSN
- 0253-6269
1976-3786
- Abstract
- A high performance liquid chromatographic method was developed and validated for the determination of urazamide in pharmaceutical preparation with novel green aqueous mobile phase modified with room temperature ionic liquids (RTILs). 1-Ethyl-3-methyl-imidazolium tetrafluoroborate ([EMIM][BF4]) was selected as a mobile phase additive to improve retention and avoid baseline disturbances at t(0). Various mobile phase parameters such as cation moiety, chaotropic anion moiety, pH and concentration of RTILs were optimized to determine urazamide at the proper retention time. The assay was validated according to International Conference on Harmonization guidelines. The linearity of the calibration curve was good (r(2) > 0.999). Intra-day precision varied between 0.50 and 1.23%. Relative standard deviations of inter-day precision ranged between 1.07 and 1.66%. Recoveries in tablets ranged between 99.7 and 101.2% and it was successfully applied to determine urazamide in pharmaceutical preparations.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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