Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Hyun Jin | - |
dc.contributor.author | Park, Joon Soon | - |
dc.contributor.author | Kim, Kyung Soo | - |
dc.contributor.author | Park, Seung Yong | - |
dc.contributor.author | Choi, Honghwan | - |
dc.contributor.author | Seo, Ju Hee | - |
dc.contributor.author | Kang, Miran | - |
dc.contributor.author | Yoon, Joo-Heon | - |
dc.contributor.author | Kim, Chang-Hoon | - |
dc.contributor.author | Kim, Sehoon | - |
dc.contributor.author | Cho, Hyung-Ju | - |
dc.date.accessioned | 2021-07-22T03:47:21Z | - |
dc.date.available | 2021-07-22T03:47:21Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0143-5221 | - |
dc.identifier.issn | 1470-8736 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47726 | - |
dc.description.abstract | The function of high-mobility group box 1 (HMGB1) varies according to its location. However, the translocation mechanism behind HMGB1 remains unclear. We hypothesize that type 2 helper T cell (Th2) cytokines are involved in the translocation of HMGB1 in the upper airway epithelium. We investigated the mechanism behind HMGB1 translocation using Th2 cytokine stimulation and examined the clinical significance of HMGB1 translocation in allergic rhinitis (AR). Cytoplasmic and extracellular HMGB1 were increased in AR. Inhibiting HMGB1 translocation with glycyrrhizic acid (GA) decreased the level of antigen-specific immunoglobulin E (IgE), the degree of Periodic Acid-Schiff (PAS), and Sirius Red staining in the murine model. The in vivo reactive oxygen species (ROS) level in the nasal mucosa was higher in the mice with AR than in the controls. Th2 cytokine-induced up-regulation of the ROS and translocation of HMGB1 by Th2 cytokines was dependent on the generated ROS. The ROS level also increased in the murine model. We suggest that the Th2 cytokine-dual oxidase (DUOX)2-ROS-HMGB1 translocation axis is important in AR pathogenesis. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PORTLAND PRESS LTD | - |
dc.title | Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1042/CS20201212 | - |
dc.identifier.bibliographicCitation | CLINICAL SCIENCE, v.135, no.3, pp 483 - 494 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000615903600004 | - |
dc.identifier.scopusid | 2-s2.0-85101496390 | - |
dc.citation.endPage | 494 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 483 | - |
dc.citation.title | CLINICAL SCIENCE | - |
dc.citation.volume | 135 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | GROUP BOX 1 | - |
dc.subject.keywordPlus | MOBILITY GROUP BOX-1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS CONTRIBUTES | - |
dc.subject.keywordPlus | NEUTROPHILIC ASTHMA | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | HMGB1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.