A polyethylene oxide-functionalized self-organized alumina nanochannel array for an immunoprotection biofilter

Abstract

Nanochannel membranes have been fabricated for many biological and engineering applications. However, due to low-throughput process, high cost, unsuitable pore geometries, and low chemical/mechanical stability, we could not have obtained optimized nanochannel membranes for biomedical treatments as well as a novel building block for artificial cell membranes. Here, we report a PEO-functionalized straight nanochannel array based on a self-organized porous alumina for a novel biofilter with antifouling, superior immunoprotection and high permeability of nutrients, which have excellent in vivo mechanical stability. Thus, our strategy may provide great advantages in novel membrane biotechnologies such as biofiltration, artificial cells, and drug delivery.