Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up
DC Field | Value | Language |
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dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Ha, Chul-Won | - |
dc.contributor.author | Lee, Choong-Hee | - |
dc.contributor.author | Park, Yong-Geun | - |
dc.date.available | 2019-03-08T09:37:18Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1471-2474 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4807 | - |
dc.description.abstract | Background: The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage. Case presentation: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 10(7)/ml and 4% hyaluronic acid (HA) hydrogel. Significant improvements in pain and function of the knee joint were identified by the evaluation at 12 months after surgery. A hyaline-like cartilage completely filled the defect and was congruent with the surrounding normal cartilage as revealed by magnetic resonance imaging (MRI), a second-look arthroscopy and histological assessment. The improved clinical outcomes maintained until 5.5 years. MRI also showed the maintenance of the restored bony and cartilaginous tissues. Conclusion: This case report suggests that the composite of allogeneic UCB-MSCs and HA hydrogel can be considered a safe and effective treatment option for large osteochondral defects of the knee. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12891-017-1422-7 | - |
dc.identifier.bibliographicCitation | BMC MUSCULOSKELETAL DISORDERS, v.18, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000395204600002 | - |
dc.identifier.scopusid | 2-s2.0-85011320176 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC MUSCULOSKELETAL DISORDERS | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Knee | - |
dc.subject.keywordAuthor | Large osteochondral defect | - |
dc.subject.keywordAuthor | Umbilical cord blood | - |
dc.subject.keywordAuthor | Mesenchymal stem cell | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordPlus | AUTOLOGOUS CHONDROCYTE IMPLANTATION | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE REPAIR | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | SURGICAL-MANAGEMENT | - |
dc.subject.keywordPlus | SUBCHONDRAL BONE | - |
dc.subject.keywordPlus | RABBIT MODEL | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | UC BLOOD | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MATRIX | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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