Nanoconfined 3D redox capacitor-based electrochemical sensor for ultrasensitive monitoring of metabolites in bacterial communication
- Authors
- Kang, Mijeong; Jo, Yeonggyu; Mun, ChaeWon; Yeom, Jinho; Park, Jong Seong; Jung, Ho Sang; Kim, Dong-Ho; Park, Sung-Gyu; Yoo, Seung Min
- Issue Date
- Oct-2021
- Publisher
- Elsevier B.V.
- Keywords
- 3D-redox-capacitor; Bacterial communication; Diagnosis; Electrochemical sensor; Signalling-related metabolite
- Citation
- Sensors and Actuators, B: Chemical, v.345
- Journal Title
- Sensors and Actuators, B: Chemical
- Volume
- 345
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/48603
- DOI
- 10.1016/j.snb.2021.130427
- ISSN
- 0925-4005
0925-4005
- Abstract
- The ability to monitor metabolites related to cell communication is important for understanding bacterial physiology, identifying bacterial species in a cellular community, and providing insights into the stage of infection. Here, we developed a nanostructured electrochemical sensor comprising a 3D-redox-capacitor-coated electrode, which was prepared by grafting a redox capacitor molecule, catechol/o-quinone, at high density to a chitosan layer. It provided high sensitivity in detecting redox-active bacterial metabolites through a redox cycling reaction in the nanoconfined structures of the electrode. We used it to monitor the secretion of signalling-related metabolites at different growth phases of Pseudomonas aeruginosa. We also used the electrode to detect signalling-related metabolites in diverse simulated body fluids mixed with P. aeruginosa culture. It was able to provide information on bacterial communication and help in sensitive diagnostic monitoring of bacterial infection. © 2021 Elsevier B.V.
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