Intracellular delivery of recombinant proteins via gold nanoparticle-DNA aptamer composites is independent of the protein physicochemical properties and cell type
DC Field | Value | Language |
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dc.contributor.author | Yeom, Ji-Hyun | - |
dc.contributor.author | Joo, Minju | - |
dc.contributor.author | Lee, Boeun | - |
dc.contributor.author | Kim, Keun Pil | - |
dc.contributor.author | Ha, Nam-Chul | - |
dc.contributor.author | Park, Yoonkyung | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.contributor.author | Lee, Kangseok | - |
dc.date.available | 2019-03-08T09:38:22Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4901 | - |
dc.description.abstract | Here, we report that the gold nanoparticle-DNA aptamer (AuNP-Apt) conjugate-based system can efficiently deliver recombinant proteins into mammalian cells in a manner independent of their size, isoelectric point, and cellular localization. Additionally, AuNP-Apt system-assisted protein delivery can be effective on primary and stem cells, indicating that its use is not limited to fast-dividing cells. We further show that the intravenously administered AuNP-Apt system can deliver proteins into rat organs. Our findings show that this system can serve as a simple, efficient, and versatile platform for the delivery of recombinant proteins into mammalian living systems. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Intracellular delivery of recombinant proteins via gold nanoparticle-DNA aptamer composites is independent of the protein physicochemical properties and cell type | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2016.09.043 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.45, pp 5 - 10 | - |
dc.identifier.kciid | ART002192000 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000391647600002 | - |
dc.identifier.scopusid | 2-s2.0-84998892617 | - |
dc.citation.endPage | 10 | - |
dc.citation.startPage | 5 | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | DNA aptamer | - |
dc.subject.keywordAuthor | Gold nanoparticle | - |
dc.subject.keywordAuthor | Protein delivery | - |
dc.subject.keywordAuthor | Intravenous delivery | - |
dc.subject.keywordPlus | COPOLYMER MICELLES | - |
dc.subject.keywordPlus | ASSISTED DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RNASE-E | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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