EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells
DC Field | Value | Language |
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dc.contributor.author | Jin, Hanyong | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Shin, Eunkyoung | - |
dc.contributor.author | Kim, Hong-Man | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.date.available | 2019-03-08T09:38:24Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4903 | - |
dc.description.abstract | Pituitary gonadotropins are key hormones that orchestrate the growth and development of ovarian follicles. However, limited information is available on intra-ovarian factors that mediate the actions of gonadotropins. In this study, we identified that the early growth response 2 gene (EGR2) is a gonadotropin-inducible gene in granulosa cells of rats and humans. Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. Overexpression of EGR2 promoted survival of KGN human granulosa-derived cells in which IER3 acts as a mediator; knockdown of EGR2 induced death in KGN cells. Additionally, EGR2 was found to regulate the expression of myeloid cell leukemia 1 (MCL-1), which belongs to the BCL-2 family of proteins regulating cell survival. Thus, this study identified a novel signaling axis, comprised of gonadotropins-EGR2-IER3, which is important for the survival of granulosa cells during folliculogenesis. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2016.11.127 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.482, no.4, pp 877 - 882 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000393720000054 | - |
dc.identifier.scopusid | 2-s2.0-85007356874 | - |
dc.citation.endPage | 882 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 877 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 482 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | KROX20 | - |
dc.subject.keywordAuthor | FSH | - |
dc.subject.keywordAuthor | LH | - |
dc.subject.keywordAuthor | Transcriptional regulation | - |
dc.subject.keywordAuthor | Target gene | - |
dc.subject.keywordPlus | HORMONAL-REGULATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CERVICAL-CANCER | - |
dc.subject.keywordPlus | GERM-CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | FAMILY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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