Recent advances in micro/nanomaterial-based aptamer selection strategiesopen access
- Authors
- Kim, Dong-Min; Go, Myeong-june; Lee, Jingyu; Na, Dokyun; Yoo, Seung-Min
- Issue Date
- Sep-2021
- Publisher
- MDPI
- Keywords
- Affinity; Aptamer; Biomolecule; Library; Screening; SELEX; Specificity
- Citation
- Molecules, v.26, no.17
- Journal Title
- Molecules
- Volume
- 26
- Number
- 17
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49140
- DOI
- 10.3390/molecules26175187
- ISSN
- 1420-3049
1420-3049
- Abstract
- Aptamers are artificial nucleic acid ligands that have been employed in various funda-mental studies and applications, such as biological analyses, disease diagnostics, targeted therapeu-tics, and environmental pollutant detection. This review focuses on the recent advances in aptamer discovery strategies that have been used to detect various chemicals and biomolecules. Recent ex-amples of the strategies discussed here are based on the classification of these micro/nanomaterial-mediated systematic evolution of ligands by exponential enrichment (SELEX) platforms into three categories: bead-mediated, carbon-based nanomaterial-mediated, and other nanoparticle-mediated strategies. In addition to describing the advantages and limitations of the aforementioned strategies, this review discusses potential strategies to develop high-performance aptamers. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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