SARS-CoV-2-Specific Antibody and T Cell Response Kinetics According to Symptom Severity
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Yeun | - |
dc.contributor.author | Kwon, Ji-Soo | - |
dc.contributor.author | Bae, Seongman | - |
dc.contributor.author | Cha, Hye Hee | - |
dc.contributor.author | Lim, Joon Seo | - |
dc.contributor.author | Kim, Min-Chul | - |
dc.contributor.author | Chung, Jin-Won | - |
dc.contributor.author | Park, Se Yoon | - |
dc.contributor.author | Lee, Myung Jin | - |
dc.contributor.author | Kim, Baek-Nam | - |
dc.contributor.author | Jung, Jiwon | - |
dc.contributor.author | Kim, Min-Jae | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.date.accessioned | 2021-09-16T06:40:17Z | - |
dc.date.available | 2021-09-16T06:40:17Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.issn | 1476-1645 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49224 | - |
dc.description.abstract | Data on the longevity of humoral and cell-mediated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19) are limited. We evaluated the detailed kinetics of antibody and T-cell responses at the acute, convalescent, and post-convalescent phases in COVID-19 patients with a wide range of severity. We enrolled patients with COVID-19 prospectively from four hospitals and one community treatment center between February 2020 and January 2021. symptom severity was classified as mild, moderate, or severe/critical. Patient blood samples were collected at 1 week (acute), 1 month (convalescent), and 2 months after symptom onset (post-convalescent). Human SARS-CoV-2 IgG and IgM antibodies were measured using in-house-developed ELISA. The SARS-CoV-2-specific T-cell responses against overlapping peptides of spike proteins and nucleoprotein were measured by interferon-g enzyme-linked immunospot assays. Twenty-five COVID-19 patients were analyzed (mild, n = 5; moderate, n = 9; severe/critical, n = 11). IgM and IgG antibody responses peaked at 1 month after symptom onset and decreased at 2 months. IgG response levels were significantly greater in the severe/critical group compared with other groups. Interferon-g-producing T-cell responses increased between 1 week and 1 month after symptom onset, and had a trend toward decreasing at 2 months, but did not show significant differences according to severity. Our data indicate that SARS-CoV-2-specific antibody responses were greater in those with severe symptoms and waned after reaching a peak around 1 month after symptom onset. However, SARS-CoV-2-specific T-cell responses were not significantly different according to symptom severity, and decreased slowly during the post-convalescent phase. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC TROP MED & HYGIENE | - |
dc.title | SARS-CoV-2-Specific Antibody and T Cell Response Kinetics According to Symptom Severity | - |
dc.type | Article | - |
dc.identifier.doi | 10.4269/ajtmh.20-1594 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.105, no.2, pp 395 - 400 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000684573800021 | - |
dc.identifier.scopusid | 2-s2.0-85114408398 | - |
dc.citation.endPage | 400 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 395 | - |
dc.citation.title | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | - |
dc.citation.volume | 105 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IGG | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalResearchArea | Tropical Medicine | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Tropical Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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