Differences in Bile Microbiology and Antibiotic Resistances between Liver Transplant Recipients and Non-Transplant Patients
DC Field | Value | Language |
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dc.contributor.author | Kang, Eunhye | - |
dc.contributor.author | Suh, Suk-Won | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Choi, Yoo Shin | - |
dc.contributor.author | Choi, Seong-Ho | - |
dc.contributor.author | Lee, Bo-Ram | - |
dc.contributor.author | Choi, YoungRok | - |
dc.contributor.author | Jeong, Jaehong | - |
dc.date.accessioned | 2021-09-16T06:40:35Z | - |
dc.date.available | 2021-09-16T06:40:35Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1096-2964 | - |
dc.identifier.issn | 1557-8674 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49239 | - |
dc.description.abstract | Background: Treatment of biliary infection in liver transplant (LT) recipients is a challenge, especially because of ineffectiveness of the antibiotic agents otherwise recommended for non-transplant populations. We aimed to understand the factors underlying the choice of antibiotic therapy. Patients and Methods: A total of 373 bile cultures from LT recipients with biliary complications (n = 127; LT group) and from a non-transplant population that underwent cholecystectomy for acute cholecystitis (n = 246; non-transplant group) between January 2009 and December 2018, were investigated. Results: Polymicrobial cultures (13.4% vs. 1.6%; p < 0.001), Enterococcus faecium (26.0% vs. 8.5%; p < 0.001), and Pseudomonas (13.4% vs. 4.1%; p = 0.001) in the LT group, and non-faecium enterococci (3.9% vs. 18.3%; p < 0.001) and Enterobacteriales (40.2% vs. 54.9%; p = 0.007), especially Escherichia (11.0% vs. 29.7%; p < 0.001), in the non-transplant group, showed higher abundance. Most of the antibiotic agents recommended as initial antibiotic therapy for the non-transplant population as per previous guidelines were not effective in LT recipients. The incidences of Enterococcus faecium (14.9% vs. 32.5%; p = 0.029) in the LT recipients with model for end-stage liver disease (MELD) score >12 and non-faecium enterococci (8.5% vs. 1.3%; p = 0.042) in those with MELD score <= 12 were higher than those in the other group. The incidence of Enterobacteriales increased over time after LT (p = 0.048) and was similar to that in the non-transplant group after one year of LT. Bile micro-organisms in LT recipients, resistant to most antibiotic agents, especially soon after LT changed over time and became similar to those in the non-transplant group after one year of LT. Conclusions: Antibiotic therapy for biliary infection in LT recipients should be different from that in non-transplant populations, considering clinical factors such as the time interval after LT and MELD score. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Differences in Bile Microbiology and Antibiotic Resistances between Liver Transplant Recipients and Non-Transplant Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/sur.2020.358 | - |
dc.identifier.bibliographicCitation | SURGICAL INFECTIONS, v.22, no.7, pp 741 - 751 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000616285300001 | - |
dc.identifier.scopusid | 2-s2.0-85114294549 | - |
dc.citation.endPage | 751 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 741 | - |
dc.citation.title | SURGICAL INFECTIONS | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | antibiotic therapy | - |
dc.subject.keywordAuthor | bacteremia | - |
dc.subject.keywordAuthor | bile micro-organisms | - |
dc.subject.keywordAuthor | biliary infection | - |
dc.subject.keywordAuthor | liver transplant | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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