Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, U. | - |
dc.contributor.author | Han, S.B. | - |
dc.contributor.author | Kwon, O.-S. | - |
dc.contributor.author | Yoo, H.H. | - |
dc.date.accessioned | 2021-09-16T06:41:00Z | - |
dc.date.available | 2021-09-16T06:41:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2233-4203 | - |
dc.identifier.issn | 2093-8950 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49261 | - |
dc.description.abstract | The purpose of this study is to investigate the in vitro metabolism of hesperetin, a bioflavonoid. Hesperetin was incubated with rat liver microsomes in the presence of NADPH and UDP-glucuronic acid for 30 min. The reaction mixture was analyzed by liquid chromatography-ion trap mass spectrometer and the chemical structures of hesperetin metabolites were characterzed based on their MS/MS spectra. As a result, a total of five metabolites were detected in rat liver microsomes. The metabolites were identified as a demethylated metabolite (eriodictyol), two hesperetin glucuronides, and two eriodictyol glucuronides. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society for Mass Spectrometry | - |
dc.title | Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometry | - |
dc.type | Article | - |
dc.identifier.doi | 10.5478/MSL.2011.2.1.020 | - |
dc.identifier.bibliographicCitation | Mass Spectrometry Letters, v.2, no.1, pp 20 - 23 | - |
dc.identifier.kciid | ART001911679 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84878639722 | - |
dc.citation.endPage | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 20 | - |
dc.citation.title | Mass Spectrometry Letters | - |
dc.citation.volume | 2 | - |
dc.type.docType | Letter | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hesperetin | - |
dc.subject.keywordAuthor | In vitro metabolism | - |
dc.subject.keywordAuthor | LC/MS | - |
dc.subject.keywordAuthor | Rat liver microsomes | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.