Crystal structure of the cofactor-free form of thioredoxin reductase from Acinetobacter baumannii
DC Field | Value | Language |
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dc.contributor.author | Chun, Hye Lin | - |
dc.contributor.author | Chang, Ye Ji | - |
dc.contributor.author | Park, Hyun Ho | - |
dc.date.accessioned | 2021-09-16T08:40:18Z | - |
dc.date.available | 2021-09-16T08:40:18Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.issn | 1873-3468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49298 | - |
dc.description.abstract | Thioredoxin reductase (TrxR) is a central component in the thioredoxin system by involving in catalyzing the reduction of thioredoxin, which is critical for organism survival. Because this system is essential, it is a promising target for novel antimicrobial agents. Herein, we solved the 1.9 angstrom high-resolution structure of TrxR from Acinetobacter baumannii Thioredoxin reductase (AbTrxR), which is a Gram-negative, pathogenic bacterium and a drug-resistant superbug. AbTrxR was cofactor-free and formed a dimer in solution. AbTrxR contained a longer dimerization loop2 and a shorter beta(7)-beta(8) connecting loop than other TrxRs. AbTrxR cofactor-free form exhibited a flavin-oxidizing (FO) conformation, whose NADPH domain was located close to the dimeric interface. This structural information might be helpful for development of new antibiotic agents targeting superbugs. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Crystal structure of the cofactor-free form of thioredoxin reductase from Acinetobacter baumannii | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/1873-3468.14149 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.595, no.15, pp 1977 - 1986 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000667735000001 | - |
dc.identifier.scopusid | 2-s2.0-85111121513 | - |
dc.citation.endPage | 1986 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1977 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 595 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Acinetobacter baumannii | - |
dc.subject.keywordAuthor | crystal structure | - |
dc.subject.keywordAuthor | redox homeostasis | - |
dc.subject.keywordAuthor | superbugs | - |
dc.subject.keywordAuthor | thioredoxin reductase | - |
dc.subject.keywordPlus | REDOX REGULATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | TOOL | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | CATALYSIS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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