Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Na Kyeong | - |
dc.contributor.author | Wang, Chi-Pin James | - |
dc.contributor.author | Lim, Jaesung | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Kwon, Ho-Keun | - |
dc.contributor.author | Kim, Se-Na | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.date.accessioned | 2021-09-23T03:40:14Z | - |
dc.date.available | 2021-09-23T03:40:14Z | - |
dc.date.issued | 2021-08-16 | - |
dc.identifier.issn | 2196-5404 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49559 | - |
dc.description.abstract | Antibodies have been widely used to provide targeting ability and to enhance bioactivity owing to their high specificity, availability, and diversity. Recent advances in biotechnology and nanotechnology permit site-specific engineering of antibodies and their conjugation to the surfaces of nanoparticles (NPs) in various orientations through chemical conjugations and physical adhesions. This study proposes the conjugation of poly(lactic-co-glycolic acid) (PLGA) NPs with antibodies by using two distinct methods, followed by a comparison between the cell-targeting efficiencies of both techniques. Full-length antibodies were conjugated to the PLGA-poly(ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) NPs through the conventional carbodiimide coupling reaction, and f(ab ')(2) antibody fragments were conjugated to the PLGA-poly(ethylene glycol)-maleimide(PLGA-PEG-Mal) NPs through interactions between the f(ab ')(2) fragment thiol groups and the maleimide located on the nanoparticle surface. The results demonstrate that the PLGA nanoparticles conjugated with the f(ab ')(2) antibody fragments had a higher targeting efficiency in vitro and in vivo than that of the PLGA nanoparticles conjugated with the full-length antibodies. The results of this study can be built upon to design a delivery technique for drugs through biocompatible nanoparticles. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities | - |
dc.title.alternative | Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s40580-021-00274-7 | - |
dc.identifier.bibliographicCitation | NANO CONVERGENCE, v.8, no.1, pp 1 - 11 | - |
dc.identifier.kciid | ART002811101 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000686664600001 | - |
dc.identifier.scopusid | 2-s2.0-85112709036 | - |
dc.citation.endPage | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NANO CONVERGENCE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Target drug delivery | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Antibody Conjugation | - |
dc.subject.keywordAuthor | Maleimide-thiol reaction | - |
dc.subject.keywordAuthor | Carbodiimide coupling | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODIES | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.