Risk Factors for Recurrent Staphylococcus aureus Bacteremia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Seong-Ho | - |
dc.contributor.author | Dagher, Michael | - |
dc.contributor.author | Ruffin, Felicia | - |
dc.contributor.author | Park, Lawrence P. | - |
dc.contributor.author | Sharma-Kuinkel, Batu K. | - |
dc.contributor.author | Souli, Maria | - |
dc.contributor.author | Morse, Alison M. | - |
dc.contributor.author | Eichenberger, Emily M. | - |
dc.contributor.author | Hale, Lauren | - |
dc.contributor.author | Kohler, Celia | - |
dc.contributor.author | Warren, Bobby | - |
dc.contributor.author | Hansen, Brenda | - |
dc.contributor.author | Medie, Felix Mba | - |
dc.contributor.author | McIntyre, Lauren M. | - |
dc.contributor.author | Fowler, Vance G., Jr. | - |
dc.date.accessioned | 2021-09-24T02:40:24Z | - |
dc.date.available | 2021-09-24T02:40:24Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.issn | 1537-6591 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49741 | - |
dc.description.abstract | Background. To understand the clinical, bacterial, and host characteristics associated with recurrent Staphylococcus aureus bacteremia (R-SAB), patients with R-SAB were compared to contemporaneous patients with a single episode of SAB (S-SAB). Methods. All SAB isolates underwent spa genotyping. All isolates from R-SAB patients underwent pulsed-field gel electrophoresis (PFGE). PFGE-indistinguishable pairs from 40 patients underwent whole genome sequencing (WGS). Acute phase plasma from R-SAB and S-SAB patients was matched 1:1 for age, race, sex, and bacterial genotype, and underwent cytokine quantification using 25-analyte multiplex bead array. Results. R-SAB occurred in 69 (9.1%) of the 756 study patients. Of the 69 patients, 30 experienced relapse (43.5%) and 39 reinfection (56.5%). Age, race, hemodialysis dependence, presence of foreign body, methicillin-resistant Staphyloccus aureus, and persistent bacteremia were individually associated with likelihood of recurrence. Multivariate risk modeling revealed that black hemodialysis patients were nearly 2 times more likely (odds ratio [OR] = 9.652 [95% confidence interval [CI], 5.402-17.418]) than white hemodialysis patients (OR = 4.53 [95% CI, 1.696-10.879]) to experience R-SAB. WGS confirmed PFGE interpretations in all cases. Median RANTES (regulated on activation, normal T cell expressed and secreted) levels in acute phase plasma from the initial episode of SAB were higher in R-SAB than in matched S-SAB controls (P = .0053, false discovery rate < 0.10). Conclusion. This study identified several risk factors for R-SAB. The largest risk for R-SAB is among black hemodialysis patients. Higher RANTES levels in R-SAB compared to matched controls warrants further study. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Risk Factors for Recurrent Staphylococcus aureus Bacteremia | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/cid/ciaa801 | - |
dc.identifier.bibliographicCitation | CLINICAL INFECTIOUS DISEASES, v.72, no.11, pp 1891 - 1899 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000670816000068 | - |
dc.identifier.scopusid | 2-s2.0-85099611008 | - |
dc.citation.endPage | 1899 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1891 | - |
dc.citation.title | CLINICAL INFECTIOUS DISEASES | - |
dc.citation.volume | 72 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordAuthor | bacteremia | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | whole genome sequencing | - |
dc.subject.keywordAuthor | health disparity | - |
dc.subject.keywordPlus | FIELD GEL-ELECTROPHORESIS | - |
dc.subject.keywordPlus | NASAL COLONIZATION | - |
dc.subject.keywordPlus | RACIAL DISPARITIES | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | REINFECTION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RELAPSE | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.