Enhancement of teprenone isomer separation by subcritical fluid chromatography using porous graphitic carbon column
DC Field | Value | Language |
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dc.contributor.author | Jin, Chang Hwa | - |
dc.contributor.author | Eom, Han Young | - |
dc.contributor.author | Bae, Seong Jun | - |
dc.contributor.author | Cho, Hyun-Deok | - |
dc.contributor.author | Han, Sang Beom | - |
dc.date.accessioned | 2021-09-24T09:40:10Z | - |
dc.date.available | 2021-09-24T09:40:10Z | - |
dc.date.issued | 2021-06-28 | - |
dc.identifier.issn | 2093-3134 | - |
dc.identifier.issn | 2093-3371 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49901 | - |
dc.description.abstract | Teprenone is a therapeutic anti-ulcer agent developed in Japan. As described in the Japanese Pharmacopoeia (JP) 17th Edition, gas chromatography/hydrogen flame ionization detection (GC/FID) and high-performance liquid chromatography/ultraviolet detection (HPLC/UV) have been used for the assay of active pharmaceutical ingredients (APIs) and teprenone capsules, respectively. The critical aspect of the assay is a separation of the structural isomers (mono-cis and all-trans) of teprenone. Herein, we propose an improved quantitative method for the quality control of teprenone in APIs and capsules via subcritical fluid chromatography/photo diode array detection (SubFC/PDA) using a porous graphitic carbon column. SubFC conditions, i.e., type and content of the organic modifier in the mobile phase, column temperature, injection volume, and flow rate, were optimized. The developed SubFC/PDA method was validated according to ICH guidelines Q2(R1) in terms of accuracy, precision (repeatability and intermediate precision), specificity, linearity, quantification range, robustness, and stability. Comparison of SubFC/PDA method with the GC/FID or HPLC/UV method (described in JP) revealed that the SubFC/PDA method gave better resolution and run time than the JP methods. The developed SubFC/PDA method is expected to be useful for pharmaceutical analysis or quality control of teprenone isomers. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER INTERNATIONAL PUBLISHING AG | - |
dc.title | Enhancement of teprenone isomer separation by subcritical fluid chromatography using porous graphitic carbon column | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s40543-021-00278-2 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, v.12, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000667676400001 | - |
dc.identifier.scopusid | 2-s2.0-85109391723 | - |
dc.citation.number | 1 | - |
dc.citation.title | JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Teprenone | - |
dc.subject.keywordAuthor | Subcritical fluid chromatography | - |
dc.subject.keywordAuthor | Mono-cis | - |
dc.subject.keywordAuthor | All-trans | - |
dc.subject.keywordAuthor | Graphitic carbon column | - |
dc.subject.keywordAuthor | Japanese Pharmacopoeia | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | GASTRIC-ULCERS | - |
dc.subject.keywordPlus | HUMAN-PLASMA | - |
dc.subject.keywordPlus | GERANYLGERANYLACETONE | - |
dc.subject.keywordPlus | TETRAPRENYLACETONE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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