Metabolically healthy obesity and the risk of all-cause and cardiovascular disease mortality in a Korean population: A prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, S.-A. | - |
dc.contributor.author | Lim, K. | - |
dc.contributor.author | Lee, J.-K. | - |
dc.contributor.author | Kang, D. | - |
dc.contributor.author | Shin, S. | - |
dc.date.accessioned | 2021-09-29T00:40:33Z | - |
dc.date.available | 2021-09-29T00:40:33Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49968 | - |
dc.description.abstract | Objectives This study aimed to examine the association between metabolically healthy obesity and all-cause and cardiovascular disease (CVD) mortality in a Korean population. Design A prospective study. Setting This study used data from the Korean Genome and Epidemiology Study. Participants A total of 140 137 participants were followed up over a median period of 9.2 years. Participants were categorised into four groups according to obesity (obese: body mass index ≥25 kg/m 2 or non-obese) and metabolic health (metabolically unhealthy: two or more metabolic abnormalities or metabolically healthy). Primary and secondary outcome measures All-cause and CVD mortality of the participants until 31 December 2018 were ascertained by the National Health Insurance Service of beneficiary status of Korea. Results Metabolically unhealthy non-obese participants were at elevated risk of all-cause mortality (HR, 1.12; 95% CI, 1.04 to 1.21; p=0.0019) and CVD mortality (HR, 1.39; 95% CI, 1.17 to 1.65; p=0.0002), particularly mortality from ischaemic heart disease (IHD) (HR, 1.54; 95% CI, 1.10 to 2.14; p=0.0116) compared with metabolically healthy non-obese participants. Surprisingly, metabolically healthy obese participants were at reduced risk of all-cause mortality (HR, 0.89; 95% CI, 0.81 to 0.98; p=0.0197). Metabolically unhealthy obese participants were at elevated risk of CVD mortality (HR, 1.51; 95% CI, 1.26 to 1.81; p<0.0001) and IHD mortality (HR, 1.88; 95% CI, 1.35 to 2.63; p=0.0002) compared with metabolically healthy non-obese participants. Conclusions In a Korean population, metabolically healthy obese participants had reduced risk of all-cause mortality compared with their non-obese counterparts, whereas metabolically unhealthy participants had elevated risk of CVD mortality, in particular mortality from IHD regardless of obesity. © 2021 BMJ Publishing Group. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMJ Publishing Group | - |
dc.title | Metabolically healthy obesity and the risk of all-cause and cardiovascular disease mortality in a Korean population: A prospective cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1136/bmjopen-2021-049063 | - |
dc.identifier.bibliographicCitation | BMJ Open, v.11, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000773615100096 | - |
dc.identifier.scopusid | 2-s2.0-85114695299 | - |
dc.citation.number | 9 | - |
dc.citation.title | BMJ Open | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | cardiac epidemiology | - |
dc.subject.keywordAuthor | epidemiology | - |
dc.subject.keywordAuthor | public health | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | HEART-DISEASE | - |
dc.subject.keywordPlus | NORMAL-WEIGHT | - |
dc.subject.keywordPlus | CONSEQUENCES | - |
dc.subject.keywordPlus | OVERWEIGHT | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | STROKE | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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