Inhalable nanoparticles delivery targeting alveolar macrophages for the treatment of pulmonary tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Chae, Jayoung | - |
dc.contributor.author | Choi, Yonghyun | - |
dc.contributor.author | Tanaka, Masayoshi | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.accessioned | 2021-10-05T04:40:09Z | - |
dc.date.available | 2021-10-05T04:40:09Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1389-1723 | - |
dc.identifier.issn | 1347-4421 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50067 | - |
dc.description.abstract | Pulmonary tuberculosis is a highly prevalent respiratory disease that affects approximately a quarter of the world's population. The drug treatment protocol for tuberculosis is complex because the Mycobacterium tuberculosis (M. tuberculosis) invades macrophages and begins to infect. Thus treatment usually includes combination therapy with several drugs such as rifampicin, pyrazinamide, isoniazid, and ethambutol over a long dosing period. Therefore, drug-delivery technologies have been developed to improve patient compliance with medication, reduce adverse effects, and increase effectiveness of the treatment. In the present review, we have discussed recent inhalable nanopharmaceutical systems for the treatment of pulmonary tuberculosis and investigated their design and effectiveness. We examined the underlying processes and characteristics of spray-drying technology and studied the formulation of a dry carrier using spray-drying method. Moreover, we reviewed various research articles on pulmonary delivery of nanoparticles using these carriers, and studied their alveolar macrophage targeting ability and therapeutic effects. Further, we appraised the effectiveness of nanoparticle inhalation therapy for the treatment of pulmonary tuberculosis and its potential as a treatment strategy for lung diseases. © 2021 The Society for Biotechnology, Japan | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Inhalable nanoparticles delivery targeting alveolar macrophages for the treatment of pulmonary tuberculosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jbiosc.2021.08.009 | - |
dc.identifier.bibliographicCitation | Journal of Bioscience and Bioengineering, v.132, no.6, pp 543 - 551 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000719441900001 | - |
dc.identifier.scopusid | 2-s2.0-85115147375 | - |
dc.citation.endPage | 551 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 543 | - |
dc.citation.title | Journal of Bioscience and Bioengineering | - |
dc.citation.volume | 132 | - |
dc.type.docType | Review | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | Alveolar macrophage targeting | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Pulmonary tuberculosis | - |
dc.subject.keywordAuthor | Spray-drying | - |
dc.subject.keywordPlus | Controlled drug delivery | - |
dc.subject.keywordPlus | Disease control | - |
dc.subject.keywordPlus | Macrophages | - |
dc.subject.keywordPlus | Spray drying | - |
dc.subject.keywordPlus | Targeted drug delivery | - |
dc.subject.keywordPlus | Tubes (components) | - |
dc.subject.keywordPlus | Alveolar macrophage targeting | - |
dc.subject.keywordPlus | Alveolar macrophages | - |
dc.subject.keywordPlus | Combination therapy | - |
dc.subject.keywordPlus | Inhalable | - |
dc.subject.keywordPlus | Macrophage targeting | - |
dc.subject.keywordPlus | Mycobacterium tuberculosis | - |
dc.subject.keywordPlus | Pulmonary tuberculosis | - |
dc.subject.keywordPlus | Pyrazinamide | - |
dc.subject.keywordPlus | Spray-drying | - |
dc.subject.keywordPlus | World population | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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