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Mix-and-read, one-minute SARS-CoV-2 diagnostic assay: development of PIFE-based aptasensoropen access
- Issue Date
- 5-Oct-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.57, no.79, pp 10222 - 10225
- Pages
- 4
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 57
- Number
- 79
- Start Page
- 10222
- End Page
- 10225
- ISSN
- 1359-7345
1364-548X
- Abstract
- We developed a one-minute, one-step SARS-CoV-2 antigen assay based on protein-induced fluorescence enhancement of a DNA aptamer. The system showed significant selectivity and sensitivity towards both nucleocapsid protein and SARS-CoV-2 virus lysate, but with marked improvements in speed and manufacturability. We hence propose this platform as a mix-and-read testing strategy for SARS-CoV-2 that can be applied to POC diagnostics in clinical settings, especially in low- and middle-income countries.
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