Effects of Extremely Low Frequency Elecromagnetic Fields on Thyroid Carcinogenesis Induced by N-bis(2-hydroxypropyl)nitrosamine and Sulfadimethoxine
DC Field | Value | Language |
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dc.contributor.author | Lee, Soo Hwan | - |
dc.contributor.author | Park, Young Jin | - |
dc.contributor.author | Park, Eon Sub | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Choi, Yoo Shin | - |
dc.contributor.author | Kim, Beom Gyu | - |
dc.contributor.author | Park, Sung Jun | - |
dc.contributor.author | Chong, Se Min | - |
dc.date.accessioned | 2021-10-20T02:40:20Z | - |
dc.date.available | 2021-10-20T02:40:20Z | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 2233-7903 | - |
dc.identifier.issn | 2093-0488 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50439 | - |
dc.description.abstract | Purpose: Long-term exposure to extremely low-frequency (60 Hz) electromagnetic fields (ELF-EMF) raises the questions of the induction of biological effects including tumorigenesis. One mechanism through which ELF-MFS could influence neoplastic development is the imbalance of cellular proliferation and cell apoptosis. The present study investigated the effect of ELF-EMF on chemically-induced thyroid carcinogenesis in a rat. Methods: We examined Cellular proliferation index measured by anti-Ki-67 antigen, apoptosis, apoptosis related proteins such as caspase 3 and p53, and cell cycle-related proteins (cyclin D1 and p21(WAF1/Cip1)). Forty Male F344 rats received a subcutaneous N-bis(2-hydroxypropyl)nitrosamine (DHPN, 2,800 mg/kg) injection, and I week later were allowed free access to drinking water containing sulfadimethoxine (0.1%) for 12 weeks. Twenty rats were exposed by ELF-EMF During the carcinogenesis, sequential histological changes from hyperplasia, adenoma, and ultimately to overt carcinomas were noted. Results: The exposure,group of ELF-EMF, significantly increases the number size of carcinomas. Also, the proliferative and apoptotic indices were significantly increased in the ELF-EMF exposure group than in the control group. The caspase 3 protein expression did not show any significant changes between ELF-EMF group and control group. The p53 protein was not detected in both ELF-EMF exposure and control group. Among the cell cycle related proteins, cyclin D1, not p21(WAF1/Cip1), was significantly increased in adenomas and carcinomas in ELF-EMF exposure group compared with the control group. Conclusion: Exposure of ELF-EMF effects on chemically-induced rat thyroid carcinogenesis as results of altered increase of cellular proliferation, apoptosis, and cyclin D1 expression. (J Korean Surg Soc 2009;77:161-169) | - |
dc.format.extent | 9 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | KOREAN SURGICAL SOCIETY | - |
dc.title | Effects of Extremely Low Frequency Elecromagnetic Fields on Thyroid Carcinogenesis Induced by N-bis(2-hydroxypropyl)nitrosamine and Sulfadimethoxine | - |
dc.type | Article | - |
dc.identifier.doi | 10.4174/jkss.2009.77.3.161 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.77, no.3, pp 161 - 169 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000270099800002 | - |
dc.citation.endPage | 169 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.title | JOURNAL OF THE KOREAN SURGICAL SOCIETY | - |
dc.citation.volume | 77 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Extremely low frequency magnetic field | - |
dc.subject.keywordAuthor | Thyroid carcinogenesis | - |
dc.subject.keywordAuthor | N-bis(2-hydroxypropyl)nitrosamine (DHPN) | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Cell cycle-related proteins | - |
dc.subject.keywordPlus | HZ MAGNETIC-FIELDS | - |
dc.subject.keywordPlus | ELECTROMAGNETIC-FIELDS | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CARCINOMAS | - |
dc.subject.keywordPlus | PROMOTION | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
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