The effects of functionalized titanium with alendronate and bone morphogenic protein-2 for improving osteoblast activity
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Lee, Deok-Won | - |
dc.contributor.author | Kim, Jung Wook | - |
dc.contributor.author | Yang, Dae Hyeok | - |
dc.contributor.author | Suh, Dong Hun | - |
dc.date.accessioned | 2021-10-21T03:40:09Z | - |
dc.date.available | 2021-10-21T03:40:09Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.issn | 2212-5469 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50491 | - |
dc.description.abstract | The aim of this study was to investigate the effect of functionalized titanium (Ti) with alendronate (Aln) and bone morphogenic protein-2 (BMP-2) for enhancement of osteoblast activity in vitro. Aln and/or BMP-2 were sequentially immobilized to the heparinized-Ti (Hep-Ti) surface. The compositions of pristine Ti and Hep-Ti with or without Aln and/or BMP-2 were characterized by scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). Aln and/or BMP-2 onto Hep-Ti surface were released in a sustained manner. Osteoblast activities on all Ti substrates were investigated by cell proliferation assays, alkaline phosphate (ALP) activity, calcium deposition, gene expressions of osteocalcin and osteopontin. Aln/BMP-2/Hep-Ti significantly enhanced ALP activity, calcium mineral deposition, and gene expressions of osteoblast cells when compared with pristine Ti, Aln/Hep-Ti, and BMP-2/Hep-Ti. From these results, functionalized Ti substrates with alendronate and BMP-2 such as Aln/BMP-2/Hep-Ti are a promising material for the enhanced osteoblast activities in orthopedic and dental fields. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.title | The effects of functionalized titanium with alendronate and bone morphogenic protein-2 for improving osteoblast activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13770-013-1098-5 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.10, no.6, pp 353 - 361 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000327431000010 | - |
dc.citation.endPage | 361 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 353 | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | alendronate | - |
dc.subject.keywordAuthor | bone morphogenic protein-2 (BMP-2) | - |
dc.subject.keywordAuthor | functionalized titanium (Ti) | - |
dc.subject.keywordAuthor | osteoblast activity | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | BACTERIAL ADHESION | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | SURFACE FUNCTIONALIZATION | - |
dc.subject.keywordPlus | MC3T3-E1 CELLS | - |
dc.subject.keywordPlus | RGD PEPTIDE | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | OSSEOINTEGRATION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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