Urinary phthalate levels associated with the risk of nonalcoholic fatty liver disease in adults: The korean national environmental health survey (konehs) 2012–2014
DC Field | Value | Language |
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dc.contributor.author | Yang, Y.-J. | - |
dc.contributor.author | Kim, T. | - |
dc.contributor.author | Hong, Y.-P. | - |
dc.date.accessioned | 2021-11-01T03:40:23Z | - |
dc.date.available | 2021-11-01T03:40:23Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1661-7827 | - |
dc.identifier.issn | 1660-4601 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50922 | - |
dc.description.abstract | The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Recent experimental studies suggested that phthalates might induce NAFLD. Therefore, this study aimed to investigate the relationship between phthalates metabolites and NAFLD in the human population. This cross-sectional analysis was performed using data from the Korean National Environmental Health Survey II (2012–2014) among Korean adults (n = 5800). NAFLD was diagnosed using the hepatic steatosis index (HSI) in the absence of other causes of chronic liver diseases. Among the participants (mean age 46 years, 47.5% male), the prevalence of NAFLD was associated with urinary levels of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate, mono-benzyl phthalate (MBzP), and monon-butyl phthalate (MnBP) compared to the reference group. In the multivariate model, the odds ratios (ORs), 95% confidence interval (CI) for NAFLD were 1.33 (1.00–1.78) and 1.39 (1.00–1.92) in the 3rd and 4th quartile of MEHHP, respectively. Based on the study findings, high levels of urinary phthalates are associated with the prevalence of NAFLD in Korean adults. Further investigation is required to elucidate the causal relationship. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Urinary phthalate levels associated with the risk of nonalcoholic fatty liver disease in adults: The korean national environmental health survey (konehs) 2012–2014 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijerph18116035 | - |
dc.identifier.bibliographicCitation | International Journal of Environmental Research and Public Health, v.18, no.11 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000660005000001 | - |
dc.identifier.scopusid | 2-s2.0-85107191153 | - |
dc.citation.number | 11 | - |
dc.citation.title | International Journal of Environmental Research and Public Health | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Hepatic steatosis index | - |
dc.subject.keywordAuthor | Korean National Environmental Health Survey | - |
dc.subject.keywordAuthor | Nonalcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Phthalates | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | disease | - |
dc.subject.keywordPlus | health risk | - |
dc.subject.keywordPlus | health survey | - |
dc.subject.keywordPlus | phthalate | - |
dc.subject.keywordPlus | urine | - |
dc.subject.keywordPlus | Korea | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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