Recent advances in ph-or/and photo-responsive nanovehicles
- Authors
- Shin, Y.; Husni, P.; Kang, K.; Lee, D.; Lee, S.; Lee, E.; Youn, Y.; Oh, K.
- Issue Date
- May-2021
- Publisher
- MDPI AG
- Keywords
- Acid-labile bond; Chemotherapy; Light; Nanovehicles; PH; Photodynamic; Photothermal; Protonation; Stimuli
- Citation
- Pharmaceutics, v.13, no.5
- Journal Title
- Pharmaceutics
- Volume
- 13
- Number
- 5
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50945
- DOI
- 10.3390/pharmaceutics13050725
- ISSN
- 1999-4923
1999-4923
- Abstract
- The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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