Betulinic Acid Suppresses de novo Lipogenesis by Inhibiting Insulin and IGF1 Signaling as Upstream Effectors of the Nutrient-Sensing mTOR Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Kyung | - |
dc.contributor.author | Park, Yejee | - |
dc.contributor.author | Shin, Minhye | - |
dc.contributor.author | Kim, Jun-Mo | - |
dc.contributor.author | Go, Gwang-woong | - |
dc.date.accessioned | 2021-11-12T01:40:16Z | - |
dc.date.available | 2021-11-12T01:40:16Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51325 | - |
dc.description.abstract | Despite its beneficial properties, effects of betulinic acid on the nutrient-sensing mTOR pathway via insulin or IGF1 signaling remain unclear. Here, we investigated whether betulinic acid reduces intracellular lipid accumulation via the nutrient-sensing pathway in HepG2 cells. Results showed that betulinic acid reduced intracellular lipid accumulation in a dose-dependent manner and inhibited the expression of de novo lipogenesis-related genes and proteins. RNA sequencing analysis revealed the transcriptional modulation of plasma membrane proteins by betulinic acid, and an in silico binding assay indicated an interaction between betulinic acid and IR or IGF1R. Furthermore, betulinic acid downregulated the post-translational modification of the canonical IRS1/PI3K/AKT-pT308 and IGF1/mTORC2/AKT-pS473 pathways, thereby reducing the activity of the mTOR/S6K/S6 pathway. These findings imply that betulinic acid suppresses hepatic lipid synthesis by inhibiting insulin and IGF1 signaling as upstream effectors of the nutrient-sensing mTOR pathway and could be a potent nutraceutical agent for the treatment of metabolic syndromes. © 2021 American Chemical Society. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Chemical Society | - |
dc.title | Betulinic Acid Suppresses de novo Lipogenesis by Inhibiting Insulin and IGF1 Signaling as Upstream Effectors of the Nutrient-Sensing mTOR Pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jafc.1c04797 | - |
dc.identifier.bibliographicCitation | Journal of Agricultural and Food Chemistry, v.69, no.42, pp 12465 - 12473 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000713054800009 | - |
dc.identifier.scopusid | 2-s2.0-85118232412 | - |
dc.citation.endPage | 12473 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | 12465 | - |
dc.citation.title | Journal of Agricultural and Food Chemistry | - |
dc.citation.volume | 69 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | betulinic acid | - |
dc.subject.keywordAuthor | de novo lipogenesis | - |
dc.subject.keywordAuthor | IGF1 | - |
dc.subject.keywordAuthor | insulin | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordPlus | Biosynthesis | - |
dc.subject.keywordPlus | Cell membranes | - |
dc.subject.keywordPlus | Insulin | - |
dc.subject.keywordPlus | Nutrients | - |
dc.subject.keywordPlus | Proteins | - |
dc.subject.keywordPlus | Betulinic acid | - |
dc.subject.keywordPlus | De novo lipogenesis | - |
dc.subject.keywordPlus | Dose-dependent manner | - |
dc.subject.keywordPlus | Hep-g2 cells | - |
dc.subject.keywordPlus | IGF1 | - |
dc.subject.keywordPlus | Lipid accumulations | - |
dc.subject.keywordPlus | Lipogenesis | - |
dc.subject.keywordPlus | Property | - |
dc.subject.keywordPlus | Sequencing analysis | - |
dc.subject.keywordPlus | Transcriptional modulation | - |
dc.subject.keywordPlus | Antibiotics | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.