Effects of progressive carotid stenosis on cerebral haemodynamics: aortic-cerebral 3D patient-specific simulation
DC Field | Value | Language |
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dc.contributor.author | Kang, Taehak | - |
dc.contributor.author | Mukherjee, Debanjan | - |
dc.contributor.author | Kim, Jeong-Min | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Ryu, Jaiyoung | - |
dc.date.accessioned | 2021-11-15T05:41:14Z | - |
dc.date.available | 2021-11-15T05:41:14Z | - |
dc.date.issued | 2021-01-01 | - |
dc.identifier.issn | 1994-2060 | - |
dc.identifier.issn | 1997-003X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51362 | - |
dc.description.abstract | We investigated the effects of atherosclerosis in the carotid region on cerebral haemodynamics. A total of 15 stenosis cases following NASCET criteria were modelled using patient-specific medical image data and an open-source package, SimVascular. The formulation adopted the stabilised Petrov-Galerkin scheme with Newtonian and incompressible assumptions. The boundary conditions employed pulsatile inflow and three-element lumped Windkessel outlet conditions with a rigid wall assumption. We present transitions in the represented CoW during stenosis progression using three-dimensional aortic-cerebral vasculature for the first time. This was driven by the conserved total cerebral blood flow to 50% carotid stenosis (CS) (P-value, P > 0.05), which deteriorated during subsequent stages of CS (P < 0.01), and the effective collateral capability of the communicating arteries (CoAs) activated from a degree of 75% and above (P < 0.0001). The prevalence of 'complete' CoW peaked at 50% CS and then declined. Despite the collateral flow, the ipsilateral hemispheric perfusion was moderately reduced (P < 0.01), and the contralateral perfusion was conserved (P > 0.05), revealing the ineffectiveness of collateral capability of CoW at the extreme stages of CS. We identified bulk cerebral auto-regulation effects of the conventional Windkessel model, demonstrating accurate flow reduction in the stenosed artery. | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Effects of progressive carotid stenosis on cerebral haemodynamics: aortic-cerebral 3D patient-specific simulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/19942060.2021.1916601 | - |
dc.identifier.bibliographicCitation | ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS, v.15, no.1, pp 830 - 847 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000650433500001 | - |
dc.identifier.scopusid | 2-s2.0-85105957774 | - |
dc.citation.endPage | 847 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 830 | - |
dc.citation.title | ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Carotid stenosis (CS) | - |
dc.subject.keywordAuthor | circle of Willis (CoW) | - |
dc.subject.keywordAuthor | cerebral haemodynamics | - |
dc.subject.keywordAuthor | three-dimensional simulation | - |
dc.subject.keywordAuthor | aortic-cerebral vasculature (ACV) | - |
dc.subject.keywordAuthor | ICA-to-CoW domain | - |
dc.subject.keywordPlus | ARTERY BLOOD-FLOW | - |
dc.subject.keywordPlus | POSTERIOR COMMUNICATING ARTERY | - |
dc.subject.keywordPlus | FINITE-ELEMENT METHODS | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | DUPLEX ULTRASONOGRAPHY | - |
dc.subject.keywordPlus | COLLATERAL CIRCULATION | - |
dc.subject.keywordPlus | CIRCLE | - |
dc.subject.keywordPlus | WILLIS | - |
dc.subject.keywordPlus | OCCLUSION | - |
dc.subject.keywordPlus | ENDARTERECTOMY | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Mechanics | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Mechanical | - |
dc.relation.journalWebOfScienceCategory | Mechanics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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