Heparin/poly(L-lysine) nanoparticle-coated polymeric microspheres for stem-cell therapy
DC Field | Value | Language |
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dc.contributor.author | Na, Kun | - |
dc.contributor.author | Kim, Sungwon | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Woo, Dae Gyun | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Chung, Hyung-Min | - |
dc.contributor.author | Park, Keun-Hong | - |
dc.date.accessioned | 2021-11-16T00:40:09Z | - |
dc.date.available | 2021-11-16T00:40:09Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.issn | 1520-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51432 | - |
dc.description.abstract | Three-dimensional microspheres have been used extensively in several biomaterials fields, in applications such as tissue-regeneration scaffolds and drug delivery systems. To apply these biomaterials as novel cell therapeutic agents, we have devised a novel method for the fabrication of nanostructured 3D scaffolds consisting of heparin/poly(l-lysine) nanoparticles on the surface of polymeric microspheres, attached via a layer-by-layer (LbL) system. The initial step of this strategy involves the creation of heparin/poly(l-lysine) nanoparticles, which were simply produced as polyion complex micelles (PICM) with diameters of 200-500 nm. In the second step, the heparin/poly(l-lysine) nanoparticles were coated onto positively charged poly(lactic-co-glycolic acid) (PLGA) pretreated with polyethyleneimine (PEI). The production of the heparin/poly(l-lysine) nanoparticles and their subsequent coating onto PLGA microspheres represents a novel method for the functionalization of the polymeric matrix, which requires the cellular active surfaces of nanoscaled heparinized surfaces as 3D scaffolds, thus creating a better microenvironment of cell adhesion and growth for use in cell therapy applications. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Heparin/poly(L-lysine) nanoparticle-coated polymeric microspheres for stem-cell therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja067707r | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.129, no.18, pp 5788 - + | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000246180200002 | - |
dc.citation.endPage | + | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 5788 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 129 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | TEMPLATES | - |
dc.subject.keywordPlus | SILICA | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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