Fully Integrated High-Speed Intravascular Optical Coherence Tomography/Near-Infrared Fluorescence Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence-Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels
DC Field | Value | Language |
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dc.contributor.author | Lee, Sunki | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Cho, Han Saem | - |
dc.contributor.author | Song, Joon Woo | - |
dc.contributor.author | Nam, Hyeong Soo | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Oh, Wang-Yuhl | - |
dc.contributor.author | Yoo, Hongki | - |
dc.contributor.author | Kim, Jin Won | - |
dc.date.accessioned | 2021-11-16T01:40:14Z | - |
dc.date.available | 2021-11-16T01:40:14Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.issn | 1941-7632 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51440 | - |
dc.description.abstract | Background-Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was to assess lipid-rich inflamed plaques in vivo using fully integrated high-speed optical coherence tomography (OCT)/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration-approved indocyanine green (ICG). Methods and Results-An integrated high-speed intravascular OCT/NIRF imaging catheter and a dual-modal OCT/NIRF system were constructed based on a clinical OCT platform. For imaging lipid-rich inflamed plaques, the Food and Drug Administration-approved NIRF-emitting ICG (2.25 mg/kg) or saline was injected intravenously into rabbit models with experimental atheromata induced by balloon injury and 12- to 14-week high-cholesterol diets. Twenty minutes after injection, in vivo OCT/NIRF imaging of the infrarenal aorta and iliac arteries was acquired only under contrast flushing through catheter (pullback speed up to <= 20 mm/s). NIRF signals were strongly detected in the OCT-visualized atheromata of the ICG-injected rabbits. The in vivo NIRF target-to-background ratio was significantly larger in the ICG-injected rabbits than in the saline-injected controls (P<0.01). Ex vivo peak plaque target-to-background ratios were significantly higher in ICG-injected rabbits than in controls (P<0.01) on fluorescence reflectance imaging, which correlated well with the in vivo target-to-background ratios (P<0.01; r=0.85) without significant bias (0.41). Cellular ICG uptake, correlative fluorescence microscopy, and histopathology also corroborated the in vivo imaging findings. Conclusions-Integrated OCT/NIRF structural/molecular imaging with a Food and Drug Administration -approved ICG accurately identified lipid-rich inflamed atheromata in coronary-sized vessels. This highly translatable dual-modal imaging approach could enhance our capabilities to detect high-risk coronary plaques. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Fully Integrated High-Speed Intravascular Optical Coherence Tomography/Near-Infrared Fluorescence Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence-Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.114.001498 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.7, no.4, pp 560 - 569 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000341205500020 | - |
dc.citation.endPage | 569 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 560 | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | indocyanine green | - |
dc.subject.keywordAuthor | molecular imaging | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordAuthor | plaque, atherosclerotic | - |
dc.subject.keywordPlus | VULNERABLE PLAQUE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CATHETER | - |
dc.subject.keywordPlus | LESION | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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