Assessment of Collagen-Induced Arthritis Using Cyanine 5.5 Conjugated with Hydrophobically Modified Glycol Chitosan Nanoparticles: Correlation with F-18-Fluorodeoxyglucose Positron Emission Tomography Data
DC Field | Value | Language |
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dc.contributor.author | Cha, Ji Hyeon | - |
dc.contributor.author | Lee, Sang Hoon | - |
dc.contributor.author | Lee, Sheen-Woo | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Moon, Dae Hyuk | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Biswal, Sandip | - |
dc.date.accessioned | 2021-11-16T02:40:06Z | - |
dc.date.available | 2021-11-16T02:40:06Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.issn | 2005-8330 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51452 | - |
dc.description.abstract | Objective: To evaluate the potential and correlation between near-infrared fluorescence (NIRF) imaging using cyanine 5.5 conjugated with hydrophobically modified glycol chitosan nanoparticles (HGC-Cy5.5) and F-18-fluorodeoxyglucose-positron emission tomography (F-18-FDG-PET) imaging of collagen-induced arthritis (CIA). Materials and Methods: We used 10 CIA and 3 normal mice. Nine days after the injecting collagen twice, microPET imaging was performed 40 minutes after the intravenous injection of 9.3 MBq F-18-FDG in 200 mu L PBS. One day later, NIRF imaging was performed two hours after the intravenous injection of HGC-cy5.5 (5 mg/kg). We assessed the correlation between these two modalities in the knees and ankles of CIA mice. Results: The mean standardized uptake values of F-18-FDG for knees and ankles were 1.68 +/- 0.76 and 0.79 +/- 0.71, respectively, for CIA mice; and 0.57 +/- 0.17 and 0.54 +/- 0.20 respectively for control mice. From the NIRF images, the total photon counts per 30 mm(2) for knees and ankles were 2.32 +/- 1.54 x 10(5) and 2.75 +/- 1.51 x 10(5), respectively, for CIA mice, and 1.22 +/- 0.27 x 10(5) and 0.88 +/- 0.24 x 10(5), respectively, for control mice. These two modalities showed a moderate correlation for knees (r = 0.604, p = 0.005) and ankles (r = 0.464, p = 0.039). Moreover, both HGC-Cy5.5 (p = 0.002) and F-18-FDG-PET (p = 0.005) imaging also showed statistically significant differences between CIA and normal mice. Conclusion: NIRF imaging using HGC-Cy5.5 was moderately correlated with F-18-FDG-PET imaging in the CIA model. As such, HGC-Cy5.5 imaging can be used for the early detection of rheumatoid arthritis. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | Assessment of Collagen-Induced Arthritis Using Cyanine 5.5 Conjugated with Hydrophobically Modified Glycol Chitosan Nanoparticles: Correlation with F-18-Fluorodeoxyglucose Positron Emission Tomography Data | - |
dc.type | Article | - |
dc.identifier.doi | 10.3348/kjr.2012.13.4.450 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.13, no.4, pp 450 - 461 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000306396600009 | - |
dc.citation.endPage | 461 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 450 | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | HGC-Cy5.5 | - |
dc.subject.keywordAuthor | F-18-FDG PET | - |
dc.subject.keywordAuthor | Near-infrared fluorescence imaging | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordPlus | NEAR-INFRARED FLUORESCENCE | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | F-18-FDG PET | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | DYES | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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