한국인 만성 변비 환자에서 프루칼로프라이드의 안전성과 유효성: 시판 후 조사
DC Field | Value | Language |
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dc.contributor.author | Yeon, Sang Eun | - |
dc.contributor.author | Kim, Su Youn | - |
dc.contributor.author | Chung, Woo Chul | - |
dc.contributor.author | Jeon, Seong Woo | - |
dc.contributor.author | Park, Soo Jung | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Choi, Myung Gyu | - |
dc.date.accessioned | 2021-11-17T02:40:12Z | - |
dc.date.available | 2021-11-17T02:40:12Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.issn | 2233-6869 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51510 | - |
dc.description.abstract | Background/Aims: Constipation is a common gastrointestinal disorder. Prucalopride is a dihydrobenzofurancarboxamide derivative with gastrointestinal prokinetic activities and is recommended as an appropriate choice in patients unresponsive to laxatives. This study assessed the safety and efficacy of prucalopride in Korean patients with chronic constipation, in whom laxatives were ineffective. Methods: This prospective, non-interventional post-marketing surveillance of prucalopride was conducted from 2012 to 2018 at 28 hospitals in Korea. Adults who received prucalopride for the symptomatic treatment of chronic constipation were included. The patients received 2 mg of prucalopride once daily or 1 mg once daily in patients older than 65 years. The baseline characteristics, adverse events (AEs), and seven-point scale of Clinical Global Impression-Improvement were collected. Results: Of 601 patients, 67.7% were female, and the mean age was 62.3 years. Three hundred patients (49.9%) were older than 65 years. At the baseline, 70.0% of patients reported less than two instances of spontaneous complete bowel movements per week. AEs were reported in 107 patients (17.7%), including headache (3.2%) and diarrhea (2.8%). Seven serious AEs (SAEs) were reported in five patients (0.8%). The SAEs were resolved without complications; there were no cases of death. All SAEs were assessed as ‘unlikely’ causality with prucalopride. In 72.7% of patients, chronic constipation was improved by the prucalopride treatment during the study period. Conclusions: This study demonstrated the promising safety and efficacy profile of prucalopride in clinical practice. Thus, prucalopride should be considered in patients with chronic constipation when bowel symptoms are refractory to simple laxatives. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한소화기학회 | - |
dc.title | 한국인 만성 변비 환자에서 프루칼로프라이드의 안전성과 유효성: 시판 후 조사 | - |
dc.title.alternative | Safety/Efficacy of Prucalopride in Korean Patients with Chronic Constipation: Post-marketing Surveillance | - |
dc.type | Article | - |
dc.identifier.doi | 10.4166/kjg.2021.099 | - |
dc.identifier.bibliographicCitation | 대한소화기학회지, v.78, no.4, pp 219 - 226 | - |
dc.identifier.kciid | ART002766837 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000788689100003 | - |
dc.identifier.scopusid | 2-s2.0-85120835948 | - |
dc.citation.endPage | 226 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 219 | - |
dc.citation.title | 대한소화기학회지 | - |
dc.citation.volume | 78 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Constipation | - |
dc.subject.keywordAuthor | Prucalopride | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | Real clinical practice | - |
dc.subject.keywordAuthor | Adverse events | - |
dc.subject.keywordPlus | FUNCTIONAL CONSTIPATION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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