Regioselective syntheses and analyses of phlorofucofuroeckol-A derivatives
DC Field | Value | Language |
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dc.contributor.author | Kim, Yongkyun | - |
dc.contributor.author | Shin, Jooseok | - |
dc.contributor.author | Shin, Hyeon-cheol | - |
dc.contributor.author | Park, Kwangyong | - |
dc.date.accessioned | 2021-11-17T03:40:10Z | - |
dc.date.available | 2021-11-17T03:40:10Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51529 | - |
dc.description.abstract | Phlorofucofuroeckol-A (PFF-A) is a phlorotannin extracted from various brown algae. PFF-A shows low toxicity when ingested and various biochemical effects, including antioxidant, anti-inflammatory, anti-cancer, and anti-allergy properties. In this study, various di-O-substituted PFF-A derivatives were synthesized by introducing alkyl or acyl groups at two specific hydroxyls out of the nine nearly equivalent phenolic OH groups present in PFF-A. The exact molecular structures of the synthesized derivatives were analyzed using two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy, which confirmed that the substituents were regioselectively introduced at the 1-OH and 6-OH positions. Small amounts of three mono-O-substituted derivatives were generated as by-products in this reaction, and their structures and regioselectivity were determined using 2D NMR spectroscopy. This study can provide insights into understanding the mechanism of action of eckol-based compounds and developing new drug candidates. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한화학회 | - |
dc.title | Regioselective syntheses and analyses of phlorofucofuroeckol-A derivatives | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bkcs.12414 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.42, no.12, pp 1624 - 1632 | - |
dc.identifier.kciid | ART002786121 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000707148400001 | - |
dc.identifier.scopusid | 2-s2.0-85117058711 | - |
dc.citation.endPage | 1632 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1624 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | brown algae | - |
dc.subject.keywordAuthor | phlorofucofuroeckol-A | - |
dc.subject.keywordAuthor | phlorotannin | - |
dc.subject.keywordAuthor | regioselective substitution | - |
dc.subject.keywordPlus | ECKLONIA-STOLONIFERA | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | PHLOROTANNINS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | DIECKOL | - |
dc.subject.keywordPlus | AKT | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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